Protein Alignment Cyp309a2 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_608689.2
• Gene: Cyp309a2 / 33439
• FlyBaseID: FBgn0041337
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 134/543 - (24%)
• Similarity: 221/543 - (40%)
• Gaps: 115/543 - (21%)

  Fly    42 LLHLLVLPIYL---YLTWHHKYW------------RKR-------GLVT-----ARPLT-LLGTY 78
            ||.|:|...:|   .|.|.:.::            ||:       ||||     .|.|| |:.||
Human    20 LLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATY 84

  Fly    79 PGLLTRKSNLVFDVQKIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSY 143
            |                    :|..|.:|...   |.|.:..|::...|:.::     |::.
Human    85 P--------------------QGFVRWLGPIT---PIINLCHPDIVRSVINTS-----DAIT--- 118

  Fly   144 LRHAKWDK----YARLNPFW-------ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTE 197
                  ||    |..|.| |       :.|..||..|.........:.|:....|:.:...::..
Human   119 ------DKDIVFYKTLKP-WLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHA 176

  Fly   198 YMTQQVAEKNNILETRDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMAS---KWTSYAF- 258
            ...:...|.:..|:..:.....|...:...|:..|:....:|.|....:.|:::   |..:..|
Human   177 KWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFR 241

  Fly   259 YMLTLFMATIVAPCSRLLLRF----RFYPKETD----EFFSNLTKESIELRLKAGDSTRT-DYLS 314
            |...|:..|   ||.|   ||    |.....||    |....||.:.::..|:|...::| |::.
Human   242 YKDFLYFLT---PCGR---RFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID 300

  Fly   315 HLLQLRDQ--KQATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASE 377
            .||...|:  |:.:.:|:...|.|.|..|:||:.:.|...||.||.:|..|::.|.|:...:...
Human   301 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDR 365

  Fly   378 --KSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQ 440
              |.::::.|:.|.:|...:.|||||...||.:.:.||...|  |.:|:.  :..|....|..:.
Human   366 EPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVV--LPDSRV--IPKGNVCNINIFA 426

  Fly   441 FHHDKQYFPEPEAFKPERFD--NGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSN 503
            .||:...:|:||.:.|.|||  |...:..|   .|:|||.|||.|:|...||..:|..|...|..
Human   427 IHHNPSVWPDPEVYDPFRFDPENAQKRSPM---AFIPFSAGPRNCIGQKFAMAEMKVVLALTLLR 488

  Fly   504 FQVV------RGRDRLIPKGDSG 520
            |:::      |....::.:.:.|
Human   489 FRILPDHREPRRTPEIVLRAEDG 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	CYP6-like	101..526	CDD:410679	114/456 (25%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	121/489 (25%)