DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	553	Identity:	129/553 - (23%)
Similarity:	222/553 - (40%)	Gaps:	135/553 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LVLPIYLYLTWHHKYWRKRGLV--TARPLTLLGTYPGLLTRKSNLVFDVQKIYDKYKGKH-RAVG 107
            :::.|:..|..:.:.|::...:  .||...|:|  ..|..:.:|..|..|.||...:.:| ..:.
Mouse    29 ILISIFPMLVSYARKWQQMRSIPSVARAYPLVG--HALYMKPNNAEFFQQLIYYTEEFRHLPIIK 91

  Fly   108 VFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFW-------ASGQSW 165
            :::...|.:.:...|....:|.|:     ..:..|:|       |..|.| |       ::|..|
Mouse    92 LWIGPVPLVALYKAENVEVILTSS-----KQIDKSFL-------YKFLQP-WLGLGLLTSTGSKW 143

  Fly   166 RRLR------------------TDAQAGISGSRL-----RQAYNIWEQGGQMLTEYMTQQVAEKN 207
            |..|                  .:.||.|..::|     ::|:|.:........:.:.:....||
Mouse   144 RTRRKMLTPTFHFTILENFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICETAMGKN 208

  Fly   208 -NILETRDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTL-------- 263
             ......|..:..|.:.|:|.|:        |.|:.|         |..:..:.|..
Mouse   209 IGAQSNNDSEYVRTVYRMSDMIY--------RRMKMP---------WLWFDLWYLVFKEGRDHKR 256

  Fly   264 -------FMATIVAPCSRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRD 321
                   |...::|.        |...::.:|.::...:..|..:.|     |..:|..||.:.|
Mouse   257 GLKCLHTFTNNVIAE--------RVKERKAEEDWTGAGRGPIPSKNK-----RKAFLDLLLSVTD 308

  Fly   322 QK--QATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMA-SEKSLDFE 383
            ::  :.:.:|:.....|.|.:|:||:..|:..:||.|..||.||:|:..|:..... |.:.:..|
Mouse   309 EEGNRLSQEDIREEVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLE 373

  Fly   384 KLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVG--------MTIMIPNYQ 440
            .|..|:||:.||.|:||:            .|:|...:.|.|.|.|||        ..|:|| |.
Mouse   374 DLKKLKYLDCVIKETLRV------------FPSVPLFARSLSEDCEVGGYKVTKGTEAIIIP-YA 425

  Fly   441 FHHDKQYFPEPEAFKPERF----DNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHIL 501
            .|.|.:|||:||.|:||||    ..|.:..     .::|||.|||.|:|...|::..|:.|..||
Mouse   426 LHRDPRYFPDPEEFRPERFFPENSQGRHPY-----AYVPFSAGPRNCIGQKFAVMEEKTILACIL 485

  Fly   502 SNFQVVRGRDR--------LIPKGDSGFGVVLQ 526
            ..|.|...:.|        ||.:.::|..:.|:
Mouse   486 RQFWVESNQKREELGLAGDLILRPNNGIWIKLK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	124/525 (24%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	125/528 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010