Protein Alignment Cyp309a2 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_608689.2
• Gene: Cyp309a2 / 33439
• FlyBaseID: FBgn0041337
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 517
• Identity: 133/517 - (25%)
• Similarity: 242/517 - (46%)
• Gaps: 76/517 - (14%)

  Fly    32 MYILASLAL---ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGT----YPGLLTRKSNLV 89
            |.::.:|::   :||...::..|:|.|:.|..::|.|:...:||.|.||    :.|:..
Mouse     1 MELIPNLSIETWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFDGMWK------ 59

  Fly    90 FDVQKIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYAR 154
            || :..|.|| ||  ..|.:|..:|.:.::|||:...|||.  .||           :.:.....
Mouse    60 FD-EDCYKKY-GK--IWGFYVGPKPILAIMDPEIIKIVLVK--ECY-----------SVFTNRPT 107

  Fly   155 LNPFW--------ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILE 211
            |.|..        :..:.|:||||......:..:|::.:.|..|.|.:|...:.:: .||...:.
Mouse   108 LGPVGFLKKSITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRRE-EEKGEPIN 171

  Fly   212 TRDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLL 276
            .:|:...|:..|:....:|::..:|..|.....:..:...|:..:..::|:..:...:.|... :
Mouse   172 MKDIFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLSTILFPFLTPIYE-M 235

  Fly   277 LRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQK-----QATHD-DLVGHAL 335
            |....:|:::..||....|...:.||.:....|.|:|..::..::.|     :|..| ::...|:
Mouse   236 LNLSIFPRDSMNFFKKFVKRMKKERLASKQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAV 300

  Fly   336 TVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLR 400
            ..:..|||.:.|::...:|.||.:|.||:||:.||...:.::..:.::.|..::||:.|:.||||
Mouse   301 IFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLR 365

  Fly   401 LSSLIPQYTKVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHHDKQYFPEPEAFKPER 458
            |            .||.|||......|||:       |..:|||.|..|.:.:|:|||:.|.|.|
Mouse   366 L------------YPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGR 418

  Fly   459 FDNGAYQELMRKG-----IFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIP 515
            |..      ..:|     |::||.:|||.|:.:..|::::|.|::.:|.||.|....:..||
Mouse   419 FSK------ENEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIP 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	CYP6-like	101..526	CDD:410679	112/441 (25%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	114/444 (26%)