Protein Alignment Cyp309a1 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_608688.3
• Gene: Cyp309a1 / 33438
• FlyBaseID: FBgn0031432
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 119/560 - (21%)
• Similarity: 210/560 - (37%)
• Gaps: 139/560 - (24%)

  Fly     1 MFTLVGLCLTIVHVAFAVVYFYLTWYHKYWD--KRGVVTAEPLTILGSYPGILINKSRSLILDVQ 63
            :..|||....:.||        |.|.:.::|  :|.....:|             ..|:.....|
Human    21 LLLLVGASWLLAHV--------LAWTYAFYDNCRRLRCFPQP-------------PRRNWFWGHQ 64

  Fly    64 DVYNKYKDKYRTVGTFITRQPQ-----LLVLDP--ALAHEILVDKFSHFRDTITSSFVGHNPDDK 121
            .:.|..::..|.:...:...||     :..:.|  :|.|..::      |..|.:| ....|.||
Human    65 GMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDII------RSVINAS-AAIAPKDK 122

  Fly   122 Y--------VAGSPFFSAGDKWKRLRSENVGGLTP----SRLKMAYSIWEQSGRKLVEYIERARR 174
            :        :......||||||.|.|..    |||    :.||....|:.:|...:....:....
Human   123 FFYSFLEPWLGDGLLLSAGDKWSRHRRM----LTPAFHFNILKPYMKIFNESVNIMHAKWQLLAS 183

  Fly   175 EQGDIIETRDLAYRFTANAMADFIWGIDAGSLSGKVGEIGDFQKTSTDWSAH--AFSSMI--RFN 235
            |....::..:.....|.:::...::..|:           ..|:..:::.|.  ..|:::  |.:
Human   184 EGSACLDMFEHISLMTLDSLQKCVFSFDS-----------HCQEKPSEYIAAILELSALVSKRHH 237

  Fly   236 KTLVAIFVRKLFSMRFFTKATDEFFLRLTQDAVNLRQGG------------------SGEGRTDY 282
            :.|:.|                :|...||.|....|:..                  ..:|..|:
Human   238 EILLHI----------------DFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDF 286

  Fly   283 LSH-------------LIQLQQRGNSIHDS--VGHALTVHLDGFETSGAVLYHMLYSLSEHHEEQ 332
            |..             |:...:.|..:.|.  ...|.|...:|.:|:.:.|..:||.|::|.|.|
Human   287 LQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351

  Fly   333 EKLRSEILEALASE--GQISYDQINNLPYLDQCFNESLRLTTPIGFFMRICTKPTQINLGDDKTL 395
            |:.|.|:.|.|...  .:|.:|.:.:||:|..|..|||||..|:....|..|:  .|.|.|.:.
Human   352 ERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQ--DIVLPDGRV- 413

  Fly   396 DLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRF--ENGAASVLTKRG--CFLPFGDGPRICLGMR 456
             :..|:..::..:..||:..::|:...:.|.||  ||     :.:|.  .|:||..|||.|:|..
Human   414 -IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPEN-----IKERSPLAFIPFSAGPRNCIGQT 472

  Fly   457 VGQLSVKTAIVHILSNYQV-----EQMKK--VPLGADSGM 489
            .....:|..:...|..::|     |..:|  :.|.|:.|:
Human   473 FAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_608688.3	CYP6-like	71..480	CDD:410679	102/475 (21%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	106/486 (22%)