Protein Alignment Cyp309a1 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_608688.3
• Gene: Cyp309a1 / 33438
• FlyBaseID: FBgn0031432
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 115/459 - (25%)
• Similarity: 182/459 - (39%)
• Gaps: 104/459 - (22%)

  Fly    89 LDPALAHEILV---DKFSHFRDTITSSFVGH-NPDDKYVAGSPFFSAG-----DKWKRLRSENVG 144
            |.|.|...||:   ||:|..|..:|.:|  | |....|:.   .|:..     |||:.|.||.
Human   128 LKPWLGEGILLSGGDKWSRHRRMLTPAF--HFNILKSYIT---IFNKSANIMLDKWQHLASEG-- 185

  Fly   145 GLTPSRLKMAYSIWEQSGRKLVEYI--------ERARREQGDIIETRDLAYRFTANAM--ADFIW 199
               .|||.|...|...:...|.:.|        ||.......|:|...|..:.:.:.:  .||::
Human   186 ---SSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLY 247

  Fly   200 GIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIRFNKT--LVAIFVRKLFSMR---FFTKATDEF 259
            .:   |..|:                       ||::.  ||..|...:...|   ..|:..|:|
Human   248 YL---SHDGR-----------------------RFHRACRLVHDFTDAVIRERRRTLPTQGIDDF 286

  Fly   260 FLRLTQ-------DAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDSVGHALTVHLDGFETSGAV 317
            |....:       |.:.|.:...|:..:|               .|....|.|....|.:|:.:.
Human   287 FKDKAKSKTLDFIDVLLLSKDEDGKALSD---------------EDIRAEADTFMFGGHDTTASG 336

  Fly   318 LYHMLYSLSEHHEEQEKLRSEILEALASEG--QISYDQINNLPYLDQCFNESLRLTTPIGFFMRI 380
            |..:||:|:.|.|.||:.|.|:.|.|....  :|.:|.:..||:|..|..|||||..|..|..|.
Human   337 LSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRC 401

  Fly   381 CTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFE----NGAASVLTKRGC 441
            ||:  .|.|.|.:.  :..|:|.::.....||:..::|:...:.|.||:    .|.:.:     .
Human   402 CTQ--DIVLPDGRV--IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPL-----A 457

  Fly   442 FLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQ-----VEQMKKVPLGADSGMGIFLNGDVELKY 501
            |:||..|||.|:|.......:|..:..:|.:::     .|..:|:.|...:..|::|.  ||...
Human   458 FIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLR--VEPLN 520

  Fly   502 TKLQ 505
            ..||
Human   521 VSLQ 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_608688.3	CYP6-like	71..480	CDD:410679	107/432 (25%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	110/446 (25%)