DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	503	Identity:	123/503 - (24%)
Similarity:	226/503 - (44%)	Gaps:	62/503 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYN---KYKDK 72
            :|..:..::|.|.|..||.:.|.|:....||..||           :::..::.::|   :..:|
Human    14 LVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLG-----------TILFYLRGLWNFDRECNEK 67

  Fly    73 YRTV-GTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKW 135
            |..: |.:..:||.|:::||.:...:||.: :|.|.:.:....:|      ::..:..|:..::|
Human    68 YGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG------FLKSALSFAEDEEW 126

  Fly   136 KRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWG 200
            ||:|:......|..:.|....|..|.|..||..: |...|....|..:|....:|.:.:...::|
Human   127 KRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL-RQEAENSKSINLKDFFGAYTMDVITGTLFG 190

  Fly   201 IDAGSLSG----------KVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAIFVRKLFSMRFFTKA 255
            ::..||:.          |:.:: ||        ...|..:|.....|..:|  :..::..|.|.
Human   191 VNLDSLNNPQDPFLKNMKKLLKL-DF--------LDPFLLLISLFPFLTPVF--EALNIGLFPKD 244

  Fly   256 TDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQ-------QRGNSIHDSVGHALTVHLDGFET 313
            ...|.....:.....|.....:.|.|:...:|..|       .:..|..:.|..::.:....::|
Human   245 VTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDT 309

  Fly   314 SGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFM 378
            :...|..::|.|:.|.:.|:||:.||...|.::..::||.:..:.|||...||:|||...:....
Human   310 TSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVT 374

  Fly   379 RICTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPD-RF-ENGAASVLTKRGC 441
            |:|.|..:||     .:.:..|:.||||.|..|||...:.|..:|.|: || :....|:...|
Human   375 RVCKKDIEIN-----GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYR-- 432

  Fly   442 FLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMK--KVPLGADS 487
            ::|||.|||.|:|||....::|.|::..|.|:..:..|  ::||..|:
Human   433 YIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	108/457 (24%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	115/478 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920