DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	526	Identity:	131/526 - (24%)
Similarity:	239/526 - (45%)	Gaps:	64/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDKYR 74
            |::....|::..|.:|.|:|:.|.|:...:.:...|:   :|..|....:.|: |.:.||.   |
Zfish     9 TLLAFLAALLVIYGSWPHRYFKKLGIPGPKAIPFFGT---MLRYKDGFHVFDM-DCFEKYG---R 66

  Fly    75 TVGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKWKRL 138
            ..|.:..|||.|.::|..:...:|:.: :|.|.:.......|...|...:|      ..|.|:|:
Zfish    67 IWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNGALYDAVSIA------EDDDWRRI 125

  Fly   139 RSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWGIDA 203
            ||......|..|||..:.|.::....||:.:.:..: :|:..:.::....::.:.:....:.:|.
Zfish   126 RSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAK-RGESADIKEFFGAYSMDVVTSTAFSVDI 189

  Fly   204 GSLSG-KVGEIGDFQKTSTDWSAHAFSSMIRFNK-----TLVAIF------VRKLFSMRFFTKAT 256
            .||:. |...:.:.:|            |::|:.     .|:|.|      :.|:....|.|..|
Zfish   190 DSLNNPKDPFVTNIKK------------MLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVT 242

  Fly   257 DEFF-----LRLTQDAVNLRQGGSGEGRTDYLSHLIQLQ------------QRGNSIHDSVGHAL 304
            |.|:     ::..:|...:.:..: :.|.|:|..::..|            ::|.|.|:.:..::
Zfish   243 DFFYAALQKIKSDRDTKTVAKDNT-KKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSM 306

  Fly   305 TVHLDGFETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLR 369
            .....|:|||.:.|..:.|:|:.:.|..:||:.||.|...::..:.|:.:.::.|||...:||||
Zfish   307 IFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQAPVDYETLMSMDYLDAALSESLR 371

  Fly   370 LTTPIGFFMRICTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAAS 434
            |........|:|.|..:||     .|.:...:.||||.|..|.|.|.:.|...|:|:||..|...
Zfish   372 LFPVAARLERVCKKTVEIN-----GLLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKE 431

  Fly   435 VLTKRGCFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMKKVPLGADSGMGIFLNGDVEL 499
            .:... .::|||.|||.|:|||..|:::|.|||.||..:.|....:..:..:.|....|:....:
Zfish   432 SIDPY-MYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNGLLSPKDPI 495

  Fly   500 KYTKLQ 505
            | .|||
Zfish   496 K-LKLQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	116/461 (25%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	120/497 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920