DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	518	Identity:	129/518 - (24%)
Similarity:	224/518 - (43%)	Gaps:	93/518 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDKYR 74
            |:|.:...::|.|..|.|.::.|.|:....|....|::    ::.::.......:...||.   :
Zfish    12 TLVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTF----LSYTKGFFNFDMECAKKYG---K 69

  Fly    75 TVGTFITRQPQLLVLDPALAHEILVDK-FSHF--RDTITSSFVGHNPDDKYVAGSPFFSA--GDK 134
            ..|.:..|.|.|:|.|..:...|:|.: :|.|  |..:.....|...|.        .||  .::
Zfish    70 VWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADG--------ISAVKDER 126

  Fly   135 WKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIW 199
            |||:|.......|..|||..:.|......:.::.:::...||.  ::.:::...::.:.:....:
Zfish   127 WKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQP--VKIKEVVAPYSLDVVTSSSF 189

  Fly   200 GIDAGSLSGK----VGEIGDFQKTSTDWSAHAFSSMIRF-----------NKTLVAIFVRKLFSM 249
            .:|..|::..    |..|.:|.|.|      .||.:|.|           .|..:::|.|.:  |
Zfish   190 SVDIDSINNPDDPFVTNIKNFLKFS------LFSPLILFLTLFPSIANLLGKMGISVFSRSI--M 246

  Fly   250 RFFTKATDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQ--------------QRGNSIHDSV 300
            .||..|     ||..:|     :.....||.|:|..:||.|              .:|.:.|:.:
Zfish   247 NFFYTA-----LRKIKD-----EHKDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEIL 301

  Fly   301 GHALTVHLDGFETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFN 365
            ..:....|.|:||:...|..:|::|:.:.:..|||..||.:....:..||||.:..:.||:...|
Zfish   302 SQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLDTPISYDALMKMDYLEMSIN 366

  Fly   366 ESLRLTTPIGFFMRICTKPTQINLGDDKTLDLEPGVT------VMVPAYQYHHDNDIYPEASEFR 424
            ||:||........|:|.|..::|           |:|      |.:|.|..:.|..::....|||
Zfish   367 ESMRLLPTAPRLERVCKKTVELN-----------GITIPKDTLVAIPTYVLNRDPQLWDSPQEFR 420

  Fly   425 PDRF--ENGAASVLTKRGCFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMK--KVPL 483
            |:||  ||.:..:   :..|:|||.|||.|:|||...:.||..:|.:|.|:.:|..|  ::||
Zfish   421 PERFSPENKSEFL---QYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	117/475 (25%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	121/492 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920