DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	121/511 - (23%)
Similarity:	218/511 - (42%)	Gaps:	57/511 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLVGLCLTIVHVAFAVVYFYLTWYHKY--WDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDV 65
            :::.|.|.|:    .:|..|.....||  :.:|||...:|..::|:.|...:.....::..:.::
  Fly     4 SMIALALFII----LLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIEL 64

  Fly    66 YNKYKDKYRTVGTFITRQPQLLVLDPALAHEILVDKFSHFRDTITSSFVGHNPDDKYVAGSPFFS 130
            :.|:... ...|.:..|.....|.||.|...|.:.:|.||   :..:.:.:|..:..::.|....
  Fly    65 HTKHTGS-PVYGIYALRDAVFFVRDPELIKLIGIKEFDHF---VNHNSMHNNIQESILSKSLISL 125

  Fly   131 AGDKWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDI---IETRDLAYRFTAN 192
            ...:||.:|:......|.|::::.|.:.:....:.|.:|:.......|.   :|.:|...||..:
  Fly   126 RDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFAND 190

  Fly   193 AMADFIWGIDAGSLSGKVGE---IGDFQKTSTDWSAHAFSSMIRFNKTLVAIFVR--KLFSMRFF 252
            .:|...:||...|...|..|   ||......:.||.        ....|.|:|.|  |:..::..
  Fly   191 VIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSV--------VKAMLYALFPRLMKVLRIQVL 247

  Fly   253 TKATDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQL-QQRGNSIHDS---------------VG 301
            .....::|..|...|:..||... ..|.|.:..|::. |||...:.|.               :.
  Fly   248 DTKNIDYFSSLVTAAMRYRQEHK-VVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLA 311

  Fly   302 HALTVHLDGFETSGAVLYHMLYSLSEHHEEQEKLRSEIL---EALASEGQ-ISYDQINNLPYLDQ 362
            ..|.....|||...:.|..:.:.|..:...|::|..||:   |.|  :|| ::||::..:.|||.
  Fly   312 QCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEEL--KGQPLTYDKLTKMKYLDM 374

  Fly   363 CFNESLRLTTPIGFFMRICTKPTQINLGDD---KTLDLEPGVTVMVPAYQYHHDNDIYPEASEFR 424
            ...|:||...|.....|.|.:  .|:|.|:   |......|..:.:|.:..|||.:.:.:...|.
  Fly   375 VVLEALRKWPPSISTDRECRQ--DIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFN 437

  Fly   425 PDRFENGAASVLTKRGCFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMKK 480
            |:||.:|.|  |..| .::|||.|||.|:|.|:..:.:|:.:..:|.|:::...|:
  Fly   438 PERFADGHA--LESR-VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	108/463 (23%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	111/473 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460908
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000