DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	116/509 - (22%)
Similarity:	228/509 - (44%)	Gaps:	74/509 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LVGLCLTIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNK 68
            |:.:||.:|.:.: ::|.:.|...|.:::|.:...:|...:|:.....:.|| |....:.:.|.:
  Fly     3 LIEICLALVVIGY-LIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKS-SFQRQLTEFYER 65

  Fly    69 YKDKYRTVGTFITRQPQLLVLDPALAHEILVDKFSHFRDTITSSFVGHNPDDKYVAGSPFFSAGD 133
            .: :::.||.|..|.|.:.:.||.|..::.|..|.||            |:.:     ||.::.|
  Fly    66 TR-QHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHF------------PNHQ-----PFITSND 112

  Fly   134 -------------KWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARR----EQGDIIE 181
                         :||.:|:......|.::::..:::..:|..:.:::::.:.:    .:|..::
  Fly   113 RLFNDMLSVMRDQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVD 177

  Fly   182 TRDLAYRFTANAMADFIWGIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAIFVRKL 246
            .:.:..:.:.:.:|...:|:...|......|..:..::.      .||..::|.|.:::..|.||
  Fly   178 MKVMCNKLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSL------VFSRGLQFFKFMLSTLVPKL 236

  Fly   247 FS---MRFFTKATDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDS------VGH 302
            ||   :..|..|..::|.||..:|:..|: .....|.|.:..|::.:   |...|.      |..
  Fly   237 FSLLKLTIFDSAKVDYFARLVVEAMQYRE-KHNITRPDMIQLLMEAK---NESEDKWTDDEIVAQ 297

  Fly   303 ALTVHLDGFETSGAVLYHMLYSLSEHHEEQEKLRSEILEA--LASEGQISYDQINNLPYLDQCFN 365
            ........||.:..::....|.|..:.:.||:|..||:|.  ..:...::||.:..:.|:|...:
  Fly   298 CFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVIS 362

  Fly   366 ESLRLTTPIGFFMRICTKPTQINLGDD---KTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDR 427
            ||||..|......|:|:|  ...|.||   |..|.:.|..:.:|....|.|:..:||..:|.|||
  Fly   363 ESLRKWTLAAATDRLCSK--DYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDR 425

  Fly   428 FENGAASVLTKRG-----CFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVE 476
            |..      .::|     .:||||.|||.|:|.|...:.||..:.::|.:|::|
  Fly   426 FSE------ERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIE 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	106/464 (23%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	108/474 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460911
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000