DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	171/494 - (34%)
Similarity:	260/494 - (52%)	Gaps:	49/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLVGLCLTIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYN 67
            |.:.|.||::    .:||.:|||...||.|||:.||.....:||:|.|...| |::..|:.|:|.
  Fly     6 TFLVLVLTLL----VLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRK-RNIAYDIDDIYE 65

  Fly    68 KYKDKYRTVGTFITRQPQLLVLDPALAHEILVDKFSHFRDTITSSFVGHNPDDKYVAGSPFFSAG 132
            ||||....||.|.||.|||||:.|...|:|....|..|.:....:|| :...|..:..:||...|
  Fly    66 KYKDTDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFV-NKKTDMILGNNPFVLTG 129

  Fly   133 DKWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQ----GDIIETRDLAYRFTANA 193
            |:||..|||.:..|:|:|:|..|.:.:...:|.||||   ||:|    .:.::..||:..:|...
  Fly   130 DEWKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYI---RRQQQMATSEGLDAMDLSLCYTTEV 191

  Fly   194 MADFIWGIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIR--FNKTLVAIF----------VRKL 246
            ::|...|:.|.|          |..|.|     ....||:  ||.:...||          |||.
  Fly   192 VSDCGLGVSAQS----------FTDTPT-----PLLKMIKRVFNTSFEFIFYSVVTNLWQKVRKF 241

  Fly   247 FSMRFFTKATDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDSV-GHALTVHLDG 310
            :|:.||.|.|:.|||.:.:..:.||.....:.|.|:|::::|||::.....|:: .:.:|..|||
  Fly   242 YSVPFFNKETEVFFLDIIRRCITLRLEKPEQQRDDFLNYMLQLQEKKGLHTDNILINTMTFILDG 306

  Fly   311 FETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIG 375
            |||:..||.|::..|..:.|||:|:|.||     ....:::||::.||:||.|..|:|||.:|..
  Fly   307 FETTALVLAHIMLMLGRNPEEQDKVRKEI-----GSADLTFDQMSELPHLDACIYETLRLFSPQV 366

  Fly   376 FFMRICTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRF---ENGAASVLT 437
            ...::.|:|.:....:.:|:.|:||..|.:|....|||...|.:...|:|:||   ..|......
  Fly   367 AARKLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYR 431

  Fly   438 KRGCFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVE 476
            .||.:|.||||||.|.|||.....:|.|:|.||.|::::
  Fly   432 DRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	152/448 (34%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	155/458 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472974
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27358
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0007607
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.010