DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and Cyp309a2

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	248/506 - (49%)
Similarity:	359/506 - (70%)	Gaps:	5/506 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTLVGLCLTIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDV 65
            |:.|..|.|.::|:....:|.||||:||||.|||:|||.|||:||:|||:|..|| :|:.|||.:
  Fly    32 MYILASLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKS-NLVFDVQKI 95

  Fly    66 YNKYKDKYRTVGTFITRQPQLLVLDPALAHEILVDKFSHFRDTITSSFVGHNPDDKYVAGSPFFS 130
            |:|||.|:|.||.|:|||||:|||||.||||:||..|..::|::.||::.|...|||...:||::
  Fly    96 YDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWA 160

  Fly   131 AGDKWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMA 195
            :|..|:|||::...|::.|||:.||:||||.|:.|.||:.:...|:.:|:|||||.:|:||:.||
  Fly   161 SGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMA 225

  Fly   196 DFIWGIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAIFVRKLFSMRFFTKATDEFF 260
            |||||||||:|:..:.:....|:.::.|:::||..:..|..|:||...|.|...||:.|.|||||
  Fly   226 DFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFF 290

  Fly   261 LRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDS-VGHALTVHLDGFETSGAVLYHMLYS 324
            ..||::::.||.......||||||||:||:.:..:.||. |||||||.|||::|||..|.|.||.
  Fly   291 SNLTKESIELRLKAGDSTRTDYLSHLLQLRDQKQATHDDLVGHALTVMLDGYDTSGTALLHALYY 355

  Fly   325 LSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFMRICTKPTQINL 389
            |:|:...|:|||.|||..:|||..:.::::::|.||:|...|||||::.|..:.::||.||.|.|
  Fly   356 LAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRL 420

  Fly   390 GDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAASVLTKRGCFLPFGDGPRICLG 454
            .:.|:||:|.|:|:|:|.||:|||...:||...|:|:||:|||...|.::|.||||.||||||:|
  Fly   421 SESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMRKGIFLPFSDGPRICMG 485

  Fly   455 MRVGQLSVKTAIVHILSNYQVEQMKK--VPLGADSGMGIFLNGDVELKYTK 503
            :.:..|::|:|:||||||:||.:.:.  :|.| |||.|:.|.|||.|:|.:
  Fly   486 VPLAMLTLKSALVHILSNFQVVRGRDRLIPKG-DSGFGVVLQGDVNLEYRR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	209/434 (48%)
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	222/457 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472970
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27358
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0007607
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.010