DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	530	Identity:	135/530 - (25%)
Similarity:	229/530 - (43%)	Gaps:	99/530 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTLVGLCL--TIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILG---SYPGILINKSRSLIL 60
            ||.|..|.:  |:|.:...::..|..|.|.::.|.|:....||..:|   ||...:.|      .
Zfish     1 MFDLSSLSVTWTLVVLVITLLLIYGVWPHGFFKKLGIPGPRPLPFVGTALSYSKGICN------F 59

  Fly    61 DVQDVYNKYKDKYRTV-GTFITRQPQLLVLDPALAHEILV-DKFSHFRDTITSSFVGHNPDDKYV 123
            |::     ...||..| |.:..|.|.|||.|..:...||| |.:|.|.:....     |||   :
Zfish    60 DIE-----CSKKYGKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNM-----NPD---L 111

  Fly   124 AGSPFFSA-----GDKWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETR 183
            .| ||...     .::|:|:||......|..|||..:.|......:.::.:|  :::....::.:
Zfish   112 VG-PFADGITLVKDERWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNME--KKDPNLPLKIK 173

  Fly   184 DLAYRFTANAMADFIWGIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAIFVRKLF- 247
            |:...::.:.:|...:.:|..|::           ...|....:..|....| .|..:|:...|
Zfish   174 DVVAPYSLDVVASSSFSVDFDSIN-----------NPDDPFVTSIKSFFNIN-PLSPLFLLLAFC 226

  Fly   248 ----------SMRFFTKATDEFF---LRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDS 299
                      .:..|:::|.:|:   ||..:|..|     ...||.|:|..:||.|...:.:.|:
Zfish   227 PSAANLLAKMGISVFSRSTTDFYYKALRKIKDEHN-----ESNGRVDFLKLMIQNQIPDDQVKDT 286

  Fly   300 VGH----ALTVH----------LDGFETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQIS 350
            ...    .||.|          |.|:||:...|.::||:|:.:.:..|||..||.:....:..|:
Zfish   287 ASEQPVKGLTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLDIPIT 351

  Fly   351 YDQINNLPYLDQCFNESLRLTTPIGFFMRICTKPTQINLGDDKTLDLEPGVT------VMVPAYQ 409
            ||.:..:.||:...:||:|:........|:|.|..:||           |:|      |.:|.|.
Zfish   352 YDALMRMDYLEMAIHESMRVFPAGPRLERVCKKTVEIN-----------GITIPKNTLVGIPLYV 405

  Fly   410 YHHDNDIYPEASEFRPDRFENGAASVLTKRGC-FLPFGDGPRICLGMRVGQLSVKTAIVHILSNY 473
            ...|.|::...:||:|:||...:.:.:.:  | |:|||.|||.|:|||...:.:|..:|.:|..|
Zfish   406 LSRDPDLWESPNEFKPERFSPESKTEINQ--CAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKY 468

  Fly   474 QVEQMKKVPL 483
            .||..|:..:
Zfish   469 TVETCKETQI 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	119/473 (25%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	124/493 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010