DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	159/519 - (30%)
Similarity:	260/519 - (50%)	Gaps:	44/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LVGLCLTIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNK 68
            :.|..|..:......:|.:|.....:|.:|||.....|.:.||:|. :|...:...:|::|:|..
  Fly     1 MFGSLLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPN-MIWPRQHFTMDMRDIYMH 64

  Fly    69 YKDKYRTVGTFITRQPQLLVLDPALAHEILVDKFSHFRDTITSSFVGHNPDDKYVAGSPFFSAGD 133
            |::.:..||.::.|.|:||||:|.|.:||.|..||||.:...|..| ....|:.||.:||...|:
  Fly    65 YRNTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMV-DIAKDRLVALNPFVLEGE 128

  Fly   134 KWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFI 198
            :|:..|:.....||..|::..::|.::....|.::| ..:...|..::..||..|||..::.|.:
  Fly   129 EWRHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFI-AIKSAGGKDLDCIDLGLRFTGESLFDCV 192

  Fly   199 WGIDAGSLSGKVGEIGDFQKTSTD------WSAHAFSSMIRFNKTL-VAIFVRKLF-------SM 249
            .||.|              :|.||      ...|..|:.   |:.| :|..|..||       ..
  Fly   193 LGIQA--------------RTFTDNPLPVVRQNHEMSAE---NRGLAIAGAVHGLFPNLPRWLRP 240

  Fly   250 RFFTKATDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGN-SIHDSVGHALTVHLDGFET 313
            :.|.::.|.|:.::..:|:.||:....| |.|:::||:::|:..: |..|...||:|...||.:|
  Fly   241 KVFPRSHDRFYGQMISEALRLRRSKHQE-RNDFINHLLEMQRELDLSEEDMASHAMTFMFDGLDT 304

  Fly   314 SGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQI-SYDQINNLPYLDQCFNESLRLTTPIGFF 377
            :...:.|.|..|..:.:.|.:|..| |:.:...|.: ..|.:.:||||..|||||||:....|:.
  Fly   305 TSNSIAHCLLLLGRNPDCQRRLYEE-LQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWA 368

  Fly   378 MRICTKPTQINLGD--DKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAASVLTKRG 440
            .:.|||..::. |.  .:.|.|.||..||||.|..|:|.|:|||...|||:||.:|......::|
  Fly   369 SKTCTKEYELR-GSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQG 432

  Fly   441 CFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMKKVPLGADSGMGIFL---NGDVELKY 501
            .||.||:|||.|:|||:|....|.|:..|:..::|....:...|.:....||:   .|.:.|::
  Fly   433 IFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLIFVGVHKGGIWLQF 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	142/449 (32%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	149/474 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472981
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0007607
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000