Protein Alignment Cyp309a1 and Cyp3a23-3a1

DIOPT Version :10

• Sequence 1: NP_608688.3
• Gene: Cyp309a1 / 33438
• FlyBaseID: FBgn0031432
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 502
• Identity: 135/502 - (26%)
• Similarity: 232/502 - (46%)
• Gaps: 70/502 - (13%)

  Fly    11 IVHVAFAVVYFYLTWYHKYWDKRGVVTAEPL----TILGSYPGILINKSRSLILDVQDVYNKYKD 71
            ::.|...::|.:.|..|..:.|:|:...:||    |:|..|.|:       ...|| :.:.||.
  Rat    14 LLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGL-------WKFDV-ECHKKYG- 69

  Fly    72 KYRTVGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPF-FSAGDK 134
              :..|.|..:.|...:.|..:...:||.: ||.|.:......||       :.|... .|..::
  Rat    70 --KIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVG-------IMGKAISVSKDEE 125

  Fly   135 WKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIW 199
            |||.|:......|..|||..:.:.||.|..||:|:   |:|:|..:..:::...::.:.:....:
  Rat   126 WKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYL---RQEKGKPVPVKEVFGAYSMDVITSTSF 187

  Fly   200 GIDAGSLSGKVGEIGDFQK--TSTDWSAHAFSSMIRFNKTLVAIFVRKLFSMRFFTKATDEFFLR 262
            |::..||:.......:..|  ...|:....|.|::.| ..|..::  ::.::..|.|.:.|||.:
  Rat   188 GVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVVLF-PFLTPVY--EMLNICMFPKDSIEFFKK 249

  Fly   263 LTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDSVGHALTVHLD-----------GFETSGA 316
            ........|.....:.|.|:|..::...   |...|...|.....::           |:|.:.:
  Rat   250 FVYRMKETRLDSVQKHRVDFLQLMMNAH---NDSKDKESHTALSDMEITAQSIIFIFAGYEPTSS 311

  Fly   317 VLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFM-RI 380
            .|..:|:||:.|.:.|:||:.||..||.::...:||.:..:.|||...||:||| .|||..: |:
  Rat   312 TLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRL-YPIGNRLERV 375

  Fly   381 CTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRF--ENGAASVLTKRG--- 440
            |.|..:||     .:.:..|..||:|:|..|.|...:||..||||:||  ||        :|
  Rat   376 CKKDVEIN-----GVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKEN--------KGSID 427

  Fly   441 --CFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMK--KVPL 483
              .:||||:|||.|:|||...:::|.|:..:|.|:..:..|  ::||
  Rat   428 PYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_608688.3	CYP6-like	71..480	CDD:410679	117/433 (27%)
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	121/441 (27%)