Protein Alignment Cyp309a1 and Cyp3a18

DIOPT Version :10

• Sequence 1: NP_608688.3
• Gene: Cyp309a1 / 33438
• FlyBaseID: FBgn0031432
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 510
• Identity: 127/510 - (24%)
• Similarity: 234/510 - (45%)
• Gaps: 81/510 - (15%)

  Fly    10 TIVHVAFAVVYFYL--TWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDK 72
            |.|.:|.:::.||:  |:.|..:.|.|:...:|:.:.|:    :.|....:.....|.|.||.
  Rat    11 TWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGT----IFNYGDGMWKFDDDCYKKYG-- 69

  Fly    73 YRTVGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKWK 136
             :..|.:...||.|.::||.:...:||.: :|.|.:......:|      ::..:...|..::||
  Rat    70 -KIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMG------FMKKAITMSEDEEWK 127

  Fly   137 RLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQ--GDIIETRDLAYRFTANAMADFIW 199
            |||:......|..:||..:.:..|.|..|   ::..|||:  |:.|..:|:...::.:.:....:
  Rat   128 RLRTILSPTFTSGKLKEMFPLMRQYGDTL---LKNLRREEAKGEPINMKDIFGAYSMDVITGTSF 189

  Fly   200 GIDAGSLSG-------KVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAI----FVRKLFSM---R 250
            |::..||:.       |..:|..||               .|:..|:::    |:..::.|   .
  Rat   190 GVNVDSLNNPQDPFVQKAKKILKFQ---------------IFDPFLLSVVLFPFLTPIYEMLNFS 239

  Fly   251 FFTKATDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQ-------QRGNSIHDSVGHALTVHL 308
            .|.:.:..||.:..:.....|...:.:.|.|:|..::..|       |:..|..:....|:....
  Rat   240 IFPRQSMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAIIFIF 304

  Fly   309 DGFETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTP 373
            .|::.:...:..::|.|:.....|:||::||..||.::..::||.:..:.|||...|||||| .|
  Rat   305 GGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNKAPVTYDALMEMEYLDMVVNESLRL-YP 368

  Fly   374 IGFFM-RICTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRF--ENGAASV 435
            |...: |:..|..:||     .:.:..|..|.:|.|..|.:.:.:.|..||.|:||  ||
  Rat   369 IATRLDRVSKKDVEIN-----GVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKEN----- 423

  Fly   436 LTKRG-----CFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMKK--VPL 483
               :|     .:||||:|||.|:|||...:|:|.|::.:|.|:.::..:|  :||
  Rat   424 ---KGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_608688.3	CYP6-like	71..480	CDD:410679	108/440 (25%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	113/450 (25%)