DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	140/494 - (28%)
Similarity:	229/494 - (46%)	Gaps:	49/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCLTIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKD 71
            |..||:    .::|.|.|..|..:.|.|:...:||..:|:   ||..:......| :..:.||.|
  Rat    14 LLATIL----VLLYLYGTSTHGNFKKLGISGPKPLPFVGN---ILAYRHGFWEFD-RHCHKKYGD 70

  Fly    72 KYRTVGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKW 135
            .:   |.:..|||.|.:.||.:...:||.: :|.|  |...||.......|.:.    .|..::|
  Rat    71 IW---GFYEGRQPILAITDPDIIKTVLVKECYSTF--TNRRSFGPAGILKKAIT----LSEDEEW 126

  Fly   136 KRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWG 200
            ||||:......|..:||..:.|..|....||:.::. ..|:|:.|..:|:...::.:.:....:|
  Rat   127 KRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKH-EAEKGNPITMKDIFGAYSMDVITGTSFG 190

  Fly   201 IDAGSLSG-------KVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAIFVRKLFSMRFFTKATDE 258
            ::..||:.       ||.::..|     ::....|.|:|.| ..|..:|  :.|.:..|.|...:
  Rat   191 VNVDSLNNPQNPFVQKVKKLLKF-----NFLDPFFLSVILF-PFLTPVF--EAFDITVFPKDVMK 247

  Fly   259 FFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGN-SIH------DSVGHALTVHLDGFETSGA 316
            ||....:.....|.....:.|.|:|..:|..|..|: ..|      :.|..::.....|:||:.:
  Rat   248 FFRTSVERMKENRMQEKVKQRLDFLQLMINSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSS 312

  Fly   317 VLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFMRIC 381
            .|...||.|:.|.:.|:||:.||..||.::..::||.:..:.|||...||:|||....|...|:|
  Rat   313 ALSFALYLLATHPDLQKKLQDEIDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVC 377

  Fly   382 TKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAASVLTKRGCFLPFG 446
            .|..:||     .:.:..|..||||.:..|.|...:||..||.|:||.......:... .:||||
  Rat   378 KKDVEIN-----GVFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPY-IYLPFG 436

  Fly   447 DGPRICLGMRVGQLSVKTAIVHILSNYQVEQMK--KVPL 483
            :|||.|:|||...:::|.|:|.:|.|:.....|  ::||
  Rat   437 NGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	126/448 (28%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	131/465 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920