Protein Alignment Cyp309a1 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_608688.3
• Gene: Cyp309a1 / 33438
• FlyBaseID: FBgn0031432
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 131/494 - (26%)
• Similarity: 228/494 - (46%)
• Gaps: 46/494 - (9%)

  Fly    11 IVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDKYRT 75
            ::.|:..::|.|.|..|..:.:.|:....||.:||:    :::..:.|.....:.|.||...:
Human    14 LLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGN----VLSYRQGLWKFDTECYKKYGKMW-- 72

  Fly    76 VGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKWKRLR 139
             ||:..:.|.|.:.||.:...:||.: :|.|.:..:...||      ::..:...:..::|||:|
Human    73 -GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG------FMKSAISLAEDEEWKRIR 130

  Fly   140 SENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWGIDAG 204
            |......|..:||..:.|..|.|..||..:.| ..|:|..:..:|:...::.:.:....:|::..
Human   131 SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRR-EAEKGKPVTLKDIFGAYSMDVITGTSFGVNID 194

  Fly   205 SLSGKVGEIGDFQKTSTDWS--AHAFSSMIRFNKTLVAIFVRKLFSMRFFTKATDEFFLRLTQDA 267
            ||:.......:..|....:.  ...|.|:|.| ..|..:|  :..::..|.|.|..|..:.....
Human   195 SLNNPQDPFVESTKKFLKFGFLDPLFLSIILF-PFLTPVF--EALNVSLFPKDTINFLSKSVNRM 256

  Fly   268 VNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDSVGHALTVHLD-----------GFETSGAVLYHM 321
            ...|.....:.|.|:|..:|..|   || .::..|.....|:           |:||:.:||...
Human   257 KKSRLNDKQKHRLDFLQLMIDSQ---NS-KETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 317

  Fly   322 LYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFM-RICTKPT 385
            ||.|:.|.:.|:||:.||...|.::...:||.:..:.|||...||:||| .|:...: |.|.|..
Human   318 LYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKKDV 381

  Fly   386 QINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAASVLTKRGCFLPFGDGPR 450
            :||     .:.:..|..|::|.|..|||...:.|..||||:||.....|:  ....:.|||.|||
Human   382 EIN-----GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI--DPYIYTPFGTGPR 439

  Fly   451 ICLGMRVGQLSVKTAIVHILSNYQVEQMK--KVPLGADS 487
            .|:|||...:::|.|::.:|.|:..:..|  ::||..|:
Human   440 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_608688.3	CYP6-like	71..480	CDD:410679	114/425 (27%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	119/437 (27%)