DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and CYP3A4

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens

Alignment Length:	506	Identity:	129/506 - (25%)
Similarity:	228/506 - (45%)	Gaps:	67/506 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDKYRT 75
            ::.|:..::|.|.|..|..:.|.|:....||..||:    :::..:...:...:.:.||.   :.
Human    14 LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGN----ILSYHKGFCMFDMECHKKYG---KV 71

  Fly    76 VGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKWKRLR 139
            .|.:..:||.|.:.||.:...:||.: :|.|.:......||      ::..:...:..::|||||
Human    72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG------FMKSAISIAEDEEWKRLR 130

  Fly   140 SENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWGIDAG 204
            |......|..:||....|..|.|..||..:.| ..|.|..:..:|:...::.:.:....:|::..
Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRR-EAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194

  Fly   205 SLSGKVGEIGDFQKTSTDW--------SAHAFSSMIRFNKTL-VAIFVRKLFS-MRFFTKATDEF 259
            ||:.......:..|....:        |...|..:|...:.| :.:|.|::.: :|...|...|.
Human   195 SLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES 259

  Fly   260 FLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQ-------QRGNSIHDSVGHALTVHLDGFETSGAV 317
            .|..||           :.|.|:|..:|..|       .:..|..:.|..::.....|:||:.:|
Human   260 RLEDTQ-----------KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313

  Fly   318 LYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFM-RIC 381
            |..::|.|:.|.:.|:||:.||...|.::...:||.:..:.|||...||:||| .||...: |:|
Human   314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL-FPIAMRLERVC 377

  Fly   382 TKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAASVLTKRG------ 440
            .|..:||     .:.:..||.||:|:|..|.|...:.|..:|.|:||        :|:.
Human   378 KKDVEIN-----GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF--------SKKNKDNIDP 429

  Fly   441 -CFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMK--KVPLGADSG 488
             .:.|||.|||.|:|||...:::|.|::.:|.|:..:..|  ::||....|
Human   430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	115/459 (25%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	122/481 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920