Protein Alignment Cyp309a1 and CYP3A7

DIOPT Version :9

• Sequence 1: NP_001259943.1
• Gene: Cyp309a1 / 33438
• FlyBaseID: FBgn0031432
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 140/528 - (26%)
• Similarity: 233/528 - (44%)
• Gaps: 102/528 - (19%)

  Fly    11 IVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDKYRT 75
            ::.|:..::|.|.|..|..:.|.|:....||..||:   .|..:......|: :.|.||:   :.
Human    14 LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN---ALSFRKGYWTFDM-ECYKKYR---KV 71

  Fly    76 VGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKWKRLR 139
            .|.:..:||.|.:.||.:...:||.: :|.|.:......||      ::..:...:..::|||:|
Human    72 WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVG------FMKNAISIAEDEEWKRIR 130

  Fly   140 SENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWGIDAG 204
            |......|..:||....|..|.|..||..:.| ..|.|..:..:.:...::.:.:....:|:...
Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRR-EAETGKPVTLKHVFGAYSMDVITSTSFGVSID 194

  Fly   205 SLSGKVGEIGDFQKTSTDWSAHAFSSMIRFN-------------------KTL-VAIFVRKLFSM 249
            ||:.......:..|           .::|||                   :.| :.:|.||:.|
Human   195 SLNNPQDPFVENTK-----------KLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVIS- 247

  Fly   250 RFFTKAT---DEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDSVGHALTVHLD-- 309
             |.||:.   .|..|:.||           :.|.|:|..:|..|   || .||..|.....|:
Human   248 -FLTKSVKQIKEGRLKETQ-----------KHRVDFLQLMIDSQ---NS-KDSETHKALSDLELM 296

  Fly   310 ---------GFETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFN 365
                     |:||:.:||..::|.|:.|.:.|:|::.||...|.::...:||.:..|.|||...|
Human   297 AQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVN 361

  Fly   366 ESLRLTTPIGFFM-RICTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFE 429
            |:||| .|:...: |:|.|..:||     .:.:..||.||:|:|..|||...:.|..:|.|:||
Human   362 ETLRL-FPVAMRLERVCKKDVEIN-----GMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF- 419

  Fly   430 NGAASVLTKRG-------CFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMK--KVPLGA 485
                   :|:.       .:.|||.|||.|:|||...:::|.|:|.:|.|:..:..|  ::||..
Human   420 -------SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477

  Fly   486 DSGMGIFL 493
            ..| |:.|
Human   478 RFG-GLLL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	124/476 (26%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	133/503 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920