DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	523	Identity:	139/523 - (26%)
Similarity:	247/523 - (47%)	Gaps:	89/523 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTLVGL-CLTIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQD 64
            :|:.:.| .|.::.:...::|.|.|..|..:.|:|:...:||..||:    ::|..:.|.....:
Mouse     3 LFSALSLDTLVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGT----VLNYYKGLWKFDME 63

  Fly    65 VYNKYKDKYRTVGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAG--- 125
            .|.||.   :|.|.|..:.|..::.||.....:||.: ||.|.          |..|.:..|
Mouse    64 CYEKYG---KTWGLFDGQIPLFVITDPETIKNVLVKECFSVFT----------NRQDFFPVGIMS 115

  Fly   126 -SPFFSAGDKWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRF 189
             |...:..::|||.|:......|...||..:.:.||.|..||:|: |...|:|..:..:|:...:
Mouse   116 KSISLAKDEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYL-RQEAEKGKPVAVKDVLGAY 179

  Fly   190 TANAMADFIWGIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIRFN-----KTLVAIF-----VR 244
            :.:.:....:|::..||:.......:..|           .::||:     ...||:|     :.
Mouse   180 SMDVIISTTFGVNIDSLNNPEDPFVENAK-----------KVLRFDYFDPLSLSVALFPFLTPIY 233

  Fly   245 KLFSMRFFTKATDEFFL----RLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDSVGHALT 305
            ::.::..|.|.:.|||.    |:|::.::.:|    :.|.|::..:::..   |...|...|...
Mouse   234 EMLNICMFPKDSIEFFKKFVDRMTENRLDSKQ----KHRVDFIYLMMEAY---NKSKDKDSHKAL 291

  Fly   306 VHLD-----------GFETSGAVLYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPY 359
            ..::           |:||:.::|...:|||:.|.:.|:||:.||.|||.::...:||.:..:.|
Mouse   292 SEIEITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEALPNKAPPTYDTVMAMEY 356

  Fly   360 LDQCFNESLRLTTPIGFFMRICTKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFR 424
            ||...||:|||........|:|.|..:||     .:.:..|.||::|:|..|||...:||..||:
Mouse   357 LDMVLNETLRLYPITNRLQRVCKKDVEIN-----GIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQ 416

  Fly   425 PDRF--ENGAASVLTKRG-----CFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMK--K 480
            |:||  ||        :|     .:||||:|||.|:|||...:::|.|::.:|.|:..:..|  :
Mouse   417 PERFSKEN--------KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQ 473

  Fly   481 VPL 483
            :||
Mouse   474 IPL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	124/470 (26%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	130/487 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920