DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a1 and Cyp3a41b

DIOPT Version :9

Sequence 1:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001098629.1	Gene:	Cyp3a41b / 100041375	MGIID:	3714859	Length:	504	Species:	Mus musculus

Alignment Length:	497	Identity:	133/497 - (26%)
Similarity:	233/497 - (46%)	Gaps:	58/497 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDKYRT 75
            ::.:...::|.|.|..|..:.|:|:...:||..||:    ::|..:.|.....:.|.||.   :|
Mouse    14 LLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGT----VLNYYKGLWKFDMECYEKYG---KT 71

  Fly    76 VGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKWKRLR 139
            .|.|..:.|..::.||.:...:||.: ||.|.:......||      .::.:...|..::|||.|
Mouse    72 WGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVG------IMSKAISISKDEEWKRYR 130

  Fly   140 SENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWGIDAG 204
            :......|..:||..:.:.||.|..||:|:.: ..|:|..:..:|:...::.:.:....:|::..
Mouse   131 ALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQ-EAEKGKPVTMKDVLGAYSIDVITSTSFGVNVD 194

  Fly   205 SLSGKVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAIF--VRKLFSMRFFTKATDEFFLRLTQDA 267
            ||:..  |....:|.........|..:: |:..|....  |.::.::..|.|.:.|||.:.....
Mouse   195 SLNNP--EDPFVEKAKGILRVDFFDPLV-FSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRM 256

  Fly   268 VNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDSVGHALTVHLD-----------GFETSGAVLYHM 321
            ...|.....:.|.|:|..::...   |:..|...|.....::           |:||:.:.|...
Mouse   257 KESRLDSKQKHRVDFLQLMMNAH---NNSKDKDSHKALSDMEITAQSIVFIFAGYETTSSTLSFT 318

  Fly   322 LYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFM-RICTKPT 385
            ||.|:.|.:.|:||:.||.|.|.::...:||.:..:.|||...||:||| .|||..: |.|.|..
Mouse   319 LYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVMEMEYLDMVLNETLRL-YPIGNRLERFCKKDV 382

  Fly   386 QINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRF--ENGAASVLTKRG-----CFL 443
            ::|     .:.:..|.|||:|:|..|||...:||..||:|:||  ||        :|     .::
Mouse   383 ELN-----GVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKEN--------KGSIDPYLYM 434

  Fly   444 PFGDGPRICLGMRVGQLSVKTAIVHILSNYQVE--QMKKVPL 483
            |||.|||.|:|||...:::|.|:..::.|:..:  |..::||
Mouse   435 PFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	121/455 (27%)
Cyp3a41b	NP_001098629.1	p450	39..494	CDD:278495	127/472 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920