Protein Alignment Slh and SLY1

DIOPT Version :9

• Sequence 1: NP_001137769.2
• Gene: Slh / 33434
• FlyBaseID: FBgn0264978
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_010475.1
• Gene: SLY1 / 851770
• SGDID: S000002597
• Length: 666
• Species: Saccharomyces cerevisiae
• Alignment Length: 673
• Identity: 226/673 - (33%)
• Similarity: 355/673 - (52%)
• Gaps: 62/673 - (9%)

  Fly     2 LTLRERQINAIKQMLNLN-----------------SQQPKALAAEPVWKILIYDRVGQDIISPII 49
            ::||:.||:||.:||.||                 :||      |.:||:||.|......||.::
Yeast    12 ISLRDMQISAILKMLFLNKDLNNNDNITTITDDIFNQQ------EIIWKVLILDIKSTATISSVL 70

  Fly    50 SIKELRELGVTLHVQLHSDRDSIPDVPAIYFCLPTDENLDRIQQDFSSGLYDVYHLNFLAPITRS 114
            .:.:|.:.|:|:|..:..||..:||||||||..||.||:|.|..|..|..|..:::||.:.:.|:
Yeast    71 RVNDLLKAGITVHSLIKQDRSPLPDVPAIYFVSPTKENIDIIVNDLKSDKYSEFYINFTSSLPRN 135

  Fly   115 KIENLAAAALHAGCVANIHRVYDQYVNFISLEDDFFILKHQQSDQLSYYAINRANTRDEEMEALM 179
            .:|:||......|....|.:|||||::||..|.:.|.|:...    :|..:|...|.:||:..|.
Yeast   136 LLEDLAQQVSITGKSDKIKQVYDQYLDFIVTEPELFSLEISN----AYLTLNDPKTTEEEITGLC 196

  Fly   180 DSIVDSLFALFVTLGNVPIIRCPRNSAAEMVARKLEKKLRENLWDARANLFHMDATQAGGGVFSF 244
            .:|.|.||...:|:.::||||..:...||::|.||..|||:.:.:..::     :|....|..|.
Yeast   197 ANIADGLFNTVLTINSIPIIRAAKGGPAEIIAEKLGTKLRDFVINTNSS-----STSTLQGNDSL 256

  Fly   245 QRPVLLLLDRNMDLATPLHHTWSYQALVHDVLDLGLNLVYVEDETASAG---ARKKP---KACDL 303
            :|.||::||||:|.|:...|:|.||.:|.|:..|..|.|.:..|:...|   ...||   |..|:
Yeast   257 ERGVLIILDRNIDFASMFSHSWIYQCMVFDIFKLSRNTVTIPLESKENGTDNTTAKPLATKKYDI 321

  Fly   304 DRNDRFWMTHKGSPFPTVAEAIQEELESYRNSEEEIKRLKTSMGIEGESDIAFSLVNDTTARLTN 368
            :.||.|||.:...|||..||.::..|.:|:....||.| ||  |:...||:..:..|| |.::..
Yeast   322 EPNDFFWMENSHLPFPEAAENVEAALNTYKEEAAEITR-KT--GVTNISDLDPNSNND-TVQIQE 382

  Fly   369 AVNSLPQLMEKKRLIDMHTKIATAILNFIKARRLDSFFEIEEKVMSKQTLDRPLLDLLRDGEFGQ 433
            .|..||:|..||..||.|..|..|:|:.::::.||:|||:|:...|.:|..| .||:|:||:...
Yeast   383 VVKKLPELTAKKNTIDTHMNIFAALLSQLESKSLDTFFEVEQDPGSTKTRSR-FLDILKDGKTNN 446

  Fly   434 AEDKLRLYII-YFICAQQLPESEQERLKEALQAAGCDLTALAYVQRWKGIMNRSPSISQATQYEG 497
            .|||||.:|: |......||:...:.::...:....|:.||.||.:.:..|..|....|....|.
Yeast   447 LEDKLRSFIVLYLTSTTGLPKDFVQNVENYFKENDYDINALKYVYKLREFMQLSNMSLQNKSLED 511

  Fly   498 GGTK-------TVSMFTKL----VSQGSSFVMEGVKNLVVKRHNLPVTKITEQVME----CRSNA 547
            |...       |:|....|    :..|...::.|:|.|:.::..:|:|.:.:.:|:    .:.|.
Yeast   512 GSDSAFKPSNLTLSGIYGLTEGKLQGGVGSLISGIKKLLPEKKTIPITNVVDAIMDPLNSSQKNL 576

  Fly   548 E-TDDYLYLDPKLLKGGEVLPKNRAPFQDAVVFMVGGGNYIEYQNLVDFIKQKQTSNVQRRIIYG 611
            | ||.|||:|||:.:|.......|..:..::||:||||||:|||||.:: ...|..| .::::||
Yeast   577 ETTDSYLYIDPKITRGSHTRKPKRQSYNKSLVFVVGGGNYLEYQNLQEW-AHSQLHN-PKKVMYG 639

  Fly   612 ASTLTNARQFLKELSALGGEIQS 634
            ::.:|...:||.|:|.||....|
Yeast   640 STAITTPAEFLNEISRLGASNSS 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_001137769.2	Sec1	1..630	CDD:301618	224/667 (34%)
SLY1	NP_010475.1	SEC1	11..661	CDD:227487	225/670 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341605
Domainoid	1	1.000	331	1.000	Domainoid score	I170
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5650
Inparanoid	1	1.050	349	1.000	Inparanoid score	I395
Isobase	1	0.950	-	0	Normalized mean entropy	S1059
OMA	1	1.010	-	-		QHG53926
OrthoFinder	1	1.000	-	-		FOG0004255
OrthoInspector	1	1.000	-	-		oto99937
orthoMCL	1	0.900	-	-		OOG6_101825
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1350
SonicParanoid	1	1.000	-	-		X3513
TreeFam	0	0.000	Not matched by this tool.
	14	13.880