DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slh and Scfd1

DIOPT Version :9

Sequence 1:	NP_001137769.2	Gene:	Slh / 33434	FlyBaseID:	FBgn0264978	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_084101.1	Gene:	Scfd1 / 76983	MGIID:	1924233	Length:	639	Species:	Mus musculus

Alignment Length:	636	Identity:	367/636 - (57%)
Similarity:	486/636 - (76%)	Gaps:	18/636 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLRERQINAIKQMLNLNSQQPKALAAEPVWKILIYDRVGQDIISPIISIKELRELGVTLHVQLHS 67
            ::||||..|:|:|||.|....|....|||||:|||||.|||||||::|:||||::|:|||:.|||
Mouse    11 SIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHS 75

  Fly    68 DRDSIPDVPAIYFCLPTDENLDRIQQDFSSGLYDVYHLNFLAPITRSKIENLAAAALHAGCVANI 132
            |||.||||||:||.:||:||:||:.||..:.||:.|:|||::.|:|||:|::|.|||.|..|..:
Mouse    76 DRDPIPDVPAVYFVMPTEENIDRLCQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQV 140

  Fly   133 HRVYDQYVNFISLEDDFFILKHQQSDQLSYYAINRANTRDEEMEALMDSIVDSLFALFVTLGNVP 197
            .:|:|||:|||:||||.|:|.:|..:.:||.||||.:..|.|||.:||:||||||..|||||.||
Mouse   141 AKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVP 205

  Fly   198 IIRCPRNSAAEMVARKLEKKLRENLWDARANLFHMDATQAGGGVFSFQRPVLLLLDRNMDLATPL 262
            ||||.|.:||||||.||:|||||||.|||.:||..|  ..|.|.||||||:|:|:|||:||||||
Mouse   206 IIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGD--PLGTGQFSFQRPLLVLVDRNIDLATPL 268

  Fly   263 HHTWSYQALVHDVLDLGLNLVYVED----ETASAGA---RKKPKACDLDRNDRFWMTHKGSPFPT 320
            ||||:||||||||||..||.|.:|:    |.:.|||   ||..|:.||...|:||..|||||||.
Mouse   269 HHTWTYQALVHDVLDFHLNRVNLEESTGVENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPE 333

  Fly   321 VAEAIQEELESYRNSEEEIKRLKTSMGIEGESDIAFSLVNDTTARLTNAVNSLPQLMEKKRLIDM 385
            |||::|:||||||..|:|:||||:.||:|||.:.|.|:::|.||:||:||:|||:|:|||||||:
Mouse   334 VAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDL 398

  Fly   386 HTKIATAILNFIKARRLDSFFEIEEKVMSKQTLDRPLLDLLRDGEFGQAEDKLRLYIIYFICAQQ 450
            ||.:|||:|..||||:||.:||.|||:|||.|||:.|||::.|.:.|..|||:||::||:|.|||
Mouse   399 HTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDVISDPDAGTPEDKMRLFLIYYISAQQ 463

  Fly   451 LP-ESEQERLKEALQAAGCDLTALAYVQRWKGIMNRSPSISQATQYEGGGTKTVSMFTKLVSQGS 514
            .| |.:.|:.|:||..|||:|:.|.|:::||.....:   |....|....||.:.:.:::::.||
Mouse   464 APSEVDLEQYKKALTDAGCNLSPLQYIKQWKAFAKMA---STPASYGNTTTKPMGLLSRVMNTGS 525

  Fly   515 SFVMEGVKNLVVKRHNLPVTKITEQVMECRSNAETDDYLYLDPKLLKGGE-VLPKNRAPFQDAVV 578
            .||||||||||:|:.|||||:|.:.:||.:||.|||||.|.|||:|:..: .:|:|::|||:|:|
Mouse   526 QFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRSNDSSVPRNKSPFQEAIV 590

  Fly   579 FMVGGGNYIEYQNLVDFIKQKQTSNVQRRIIYGASTLTNARQFLKELSALG 629
            |:||||||||||||||:||.||    .:.|:||.|.:.||.||:|:||.||
Mouse   591 FVVGGGNYIEYQNLVDYIKAKQ----GKHILYGCSEIFNATQFIKQLSQLG 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_001137769.2	Sec1	1..630	CDD:301618	367/636 (58%)
Scfd1	NP_084101.1	Sec1	41..626	CDD:307231	343/593 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831635
Domainoid	1	1.000	691	1.000	Domainoid score	I135
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5650
Inparanoid	1	1.050	727	1.000	Inparanoid score	I617
Isobase	1	0.950	-	0	Normalized mean entropy	S1059
OMA	1	1.010	-	-		QHG53926
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004255
OrthoInspector	1	1.000	-	-		oto94312
orthoMCL	1	0.900	-	-		OOG6_101825
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1350
SonicParanoid	1	1.000	-	-		X3513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.880