Protein Alignment Slh and STXBP3

DIOPT Version :9

• Sequence 1: NP_001137769.2
• Gene: Slh / 33434
• FlyBaseID: FBgn0264978
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_009200.2
• Gene: STXBP3 / 6814
• HGNCID: 11446
• Length: 592
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 129/641 - (20%)
• Similarity: 257/641 - (40%)
• Gaps: 131/641 - (20%)

  Fly    29 EPVWKILIYDRVGQDIISPIISIKELRELGVTLHVQLHSDRDSIPDVPAIYFCLPTDENLDRIQQ 93
            |..|||::.|.....:::....:.:|.|.|:|:...::.:|:.:..:.|:||..||.:::|....
Human    29 EGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLH 93

  Fly    94 DFSS-------GLYDVYHLNFLAPITRSKIENLAAAALHAGCVANIHRVYDQYVNFISLEDDFFI 151
            ||:|       ..| :|..:|......:||:        |.|..:|.|..:..::||..|...:.
Human    94 DFASKSENKYKAAY-IYFTDFCPDNLFNKIK--------ASCSKSIRRCKEINISFIPHESQVYT 149

  Fly   152 LKHQQSDQLSY-YAINRANTRDEEMEALMDSIVDSLFALFVTLGNVPIIRC---PRNSAAEMVAR 212
            |  ...|...| |:.:..|.:.:  :|:|:::.|.:..:..||...|.:|.   |.::|::: |:
Human   150 L--DVPDAFYYCYSPDPGNAKGK--DAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKL-AQ 209

  Fly   213 KLEKKLRENLWDARANLFHMDATQAGGGVFSFQRPVLLLLDRNMDLATPLHHTWSYQALVHDVLD 277
            .:||||.:        .:.:|......|....|   ||::||..|..:.:.|..::||:.:|:|.
Human   210 LVEKKLED--------YYKIDEKSLIKGKTHSQ---LLIIDRGFDPVSTVLHELTFQAMAYDLLP 263

  Fly   278 LGLNLVYVEDETASAGARKKPKACDLDRNDRFWMTHKGSPFPTVAEAI---QEELESYRNSEEEI 339
                   :|::|.......|.|...|:..|..|:..:......|.|.|   .:|:.|.:.:.|.
Human   264 -------IENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEG- 320

  Fly   340 KRLKTSMGIEGESDIAFSLVNDTTARLTNAVNSLPQLMEKKRLIDMHTKIATAILNFIKARRLDS 404
               |||:                 :.||..:..:|...::.....:|..:|...:|..|
Human   321 ---KTSL-----------------SALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFK------ 359

  Fly   405 FFEIEEKVMSKQTLD--------------RPLLDLLRDGEFGQAEDKLRLYIIYFICAQQLPESE 455
             ..||:...::|.|.              |.||.:|.:...... ||:|..::|........|..
Human   360 -LNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNC-DKIRAILLYIFSINGTTEEN 422

  Fly   456 QERLKEALQAAG-CDLTALAYVQRWK--GIMNRSPSISQATQYEGGGTKTVSMFTKLVSQGSSFV 517
            .:||.:.::... .|:     ::.|.  |:    |.:.|:.|.:.......:..|..:|:.:.|:
Human   423 LDRLIQNVKIENESDM-----IRNWSYLGV----PIVPQSQQGKPLRKDRSAEETFQLSRWTPFI 478

  Fly   518 MEGVKNLVVKRHNLPVTKITEQVMECRSNAETDDYLYLDPKLLKGGEVLPKNRAP----FQD--- 575
            .:                |.|..::.|.:::...|....|.:..|...:...:.|    .:|
Human   479 KD----------------IMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKN 527

  Fly   576 ---AVVFMVGGGNYIEYQNLVDFIKQKQTSNVQRRIIYGASTLTNARQFLKELSAL 628
               .:||::||..|.|.:...:..:..::..|    |.|::.:...::.|.::..|
Human   528 GSKLIVFVIGGITYSEVRCAYEVSQAHKSCEV----IIGSTHVLTPKKLLDDIKML 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_001137769.2	Sec1	1..630	CDD:301618	129/641 (20%)
STXBP3	NP_009200.2	Mediates interaction with DOC2B. /evidence=ECO:0000250	1..255		59/250 (24%)
		Sec1	33..569	CDD:307231	125/625 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910