Protein Alignment Slh and Vps33B

DIOPT Version :10

• Sequence 1: NP_995614.1
• Gene: Slh / 33434
• FlyBaseID: FBgn0264978
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_651395.1
• Gene: Vps33B / 43077
• FlyBaseID: FBgn0039335
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 131/710 - (18%)
• Similarity: 242/710 - (34%)
• Gaps: 215/710 - (30%)

  Fly     2 LTLRER----QINAIKQMLNLNSQQP--KALAAEPVWKILIYDRVGQDIISP---IISIKELREL 57
            |||.::    |:.|.:::.::....|  |.|..||            |:|.|   :::...|:..
  Fly     3 LTLDKKLQGFQLVAQEKLCSILCSIPGKKELILEP------------DLIKPLEHVVTASWLKLK 55

  Fly    58 GVTLHVQLHSDRDSIP---DVPAIYF---CLPTDENLDRIQQDFSSGLYDVYHLNFLAPITRSKI 116
            |:. .:..|....|:|   |...||.   .|.|.:.|                |..|.|:...::
  Fly    56 GIQ-RIYKHDAAQSLPRSADQVHIYMIRSVLGTFQTL----------------LKQLQPVASEEM 103

  Fly   117 ENLAAAALHAGCVANIHRVYDQYV----------------NFISLEDDFFILKHQQSDQLSYYAI 165
            .:::....|..||.:.:..:...:                :||..:.....|:.....:..|...
  Fly   104 PDISMKMYHIVCVPSCYSYFQTLLEQAGLYGLVQLHHFNWDFIYFDQGVLSLELPNLYECLYLQK 168

  Fly   166 NRANTRDEEMEALMDSIVDSLFALFVTLGNVPIIRCPRNSAAEM--VARKLEKKLRENLWDARAN 228
            |.:.         :.::..||..|.:..|...:|....:.::::  :|:.|.|      ..|..|
  Fly   169 NTSP---------LPAVAQSLRLLQMICGQPSLILSFGHHSSQLMQMAKTLGK------LPAPTN 218

  Fly   229 LFHMDATQAGGGVFSFQRPVLLLLDRNMDLATPLHHTWSYQALVHDVLDLGLNLVYVED------ 287
                 ....||         .|::||:.|....|.....|..|:.:|.:.....:.|::
  Fly   219 -----PPDYGG---------WLVIDRDKDYPASLLTPAIYAGLLLEVFEHSSGEILVDNSKNKIR 269

  Fly   288 ---------ETASAGARKKPKACDLDRN---DRFWMTHKGSPFPTVAEAIQEELESYRNSEEEIK 340
                     :.:..|.....|.|.:..|   |..:..::...|..|:..|..:::
  Fly   270 SQRVELLQGKKSKIGVNSASKPCSIRLNSTSDEIYGDNRYKRFAQVSSLIHAQVK---------- 324

  Fly   341 RLKTSMGIEGE--SDIAFSLVNDTTARLTNAVNSLPQLMEKKRLIDMHTKIATAIL----NFIKA 399
                ::|:|.:  :|:....::|..||      .||:|.|.|..:..|...:..::    ||.|.
  Fly   325 ----ALGLELQKLNDMQLDEMHDYVAR------KLPKLTELKSKVLRHLNASEIVIQMMGNFRKL 379

  Fly   400 RRLDSFFEIEEKVMSKQTLDRPL--LDLLRDGEFGQAEDKLRLYIIYFICAQQLPESEQ------ 456
            :.|      ||.:::..:..|.|  :|.|...: ||..:.|||..:...|....||..|
  Fly   380 QTL------EEDILNNDSRKRLLSEIDELLTTD-GQRFNTLRLLCLLHHCVGVAPEELQIFARNY 437

  Fly   457 ------ERLKEALQAAGCDLTALAYVQR-------------------WKGIMNRSPSISQATQYE 496
                  :.|....|.:...|.....|::                   ::...||...::.:...:
  Fly   438 CNLFGHQELGVFQQLSQAGLLPPLVVEKKAPTKLLSNLPLPKFQQTEFQANANRLKLLTSSGDGQ 502

  Fly   497 GGGTKTVSMFTKLVSQGSSFVMEGVKNLVVKRHNLP-VTKITEQVMECRSNAETDD--------Y 552
            .||:.:.|..:.| ....|||..|.        .:| |.::...:::..|..|...        :
  Fly   503 DGGSSSKSQSSGL-QTCPSFVFNGT--------YIPLVAQLCSILLKINSAEELSSKLGMIEGLH 558

  Fly   553 LYLDPKLLKGGEVLPK--------NRAPFQD--------AVVFMVGGGNYIEYQNLVDFI 596
            |:||     .|::.||        |....||        ..||:|||.:|.|.. ..||:
  Fly   559 LHLD-----SGKITPKAYASQVKLNGVADQDMFPLRLRNLFVFIVGGASYAEIA-ACDFV 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_995614.1	Sec1	33..624	CDD:460020	121/673 (18%)
Vps33B	NP_651395.1	Sec1	31..634	CDD:460020	125/682 (18%)