DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slh and Vps45

DIOPT Version :9

Sequence 1:	NP_001137769.2	Gene:	Slh / 33434	FlyBaseID:	FBgn0264978	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	636	Identity:	147/636 - (23%)
Similarity:	272/636 - (42%)	Gaps:	129/636 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PVWKILIYDRVGQDIISPIISIKELRELGVTLHVQLHSDR--DSIPDVPAIYFCLPTDENLDRIQ 92
            |..||::.|:....|||...|..::.:..|.|..:|.|.|  :.:..:..|.|..||.:|:..:.
  Fly    20 PGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLKYLKCIVFIRPTKQNIQLLA 84

  Fly    93 QDFSSGLYDVYHLNFLAPITRSKIENLAAAALHAGC--VANIHRVYDQYVNFISLEDDFFILKHQ 155
            .:..:..|..|::.|...|.|:.|:.||.      |  ..::..|.:.|.:::.:..:.|.|...
  Fly    85 NELRNPKYSAYYIYFSNIIPRTDIKYLAE------CDESESVREVKELYADYLCVNPNLFSLGIP 143

  Fly   156 Q-SDQLSYY--AINRANTRDEEMEALMDSIVDSLFALFVTLGNVPIIRCPRNS-AAEMVARKLEK 216
            . ...|::.  |:||:              :..:.|:.::|...|:||....| ||:::|:.:.:
  Fly   144 NCMANLNWLPDALNRS--------------MQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYE 194

  Fly   217 KL--RENLWDARANLFHMDATQAGGGVFSFQRPVLLLLDRNMDLATPLHHTWSYQALVHDVLDLG 279
            ::  ..:|:|.|:|   ||....         |:||:|||..|..|||.|.|:|||:||::|.:.
  Fly   195 QITKESSLFDFRSN---MDGAAP---------PLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIK 247

  Fly   280 LNLVYVEDETASAGARKKPKACDL--DRNDRFWMTHKGSPFPTVAEAIQEELESYRNSEEEIKRL 342
            .|.:   |.:......|..|...|  |::| |:..:..:.:..:...|::.:|.::....:.|::
  Fly   248 NNRL---DLSNCPNVPKDFKELVLSGDQDD-FYGNNMYANYGEIGSTIKQLMEEFQRKANDHKKV 308

  Fly   343 KTSMGIEGESDIAFSLVNDTTARLTNAVNSLPQLMEKKRLIDMHTKIATAILNFIKARRLDSFFE 407
                              ::.|.:.|.:.|.||..:....:..|..:...:......|.|....|
  Fly   309 ------------------ESIADMKNFIESYPQFKKMSGTVQKHLCVIGELSALSNKRNLFEVSE 355

  Fly   408 IEEKVMSK-------QTLDRPLLDLLRDGEFGQAEDKLRLYIIYFICAQQLPESEQERLKEALQA 465
            :|:::..|       |.:.:.:.|     |....:|.|:|..:|.:        ..||      .
  Fly   356 LEQEIACKAEHSAQLQRIKKLIAD-----ERVSIDDALKLVALYAL--------RYER------H 401

  Fly   466 AGCDLTALAYVQRWKGIMNRSPSISQATQYEGGGTKTVSMF-----------TKLVSQGSSFVME 519
            |.||.:.|..:.:.:|  .|:..:....:|.|...:...:|           |:.:.:|    ::
  Fly   402 ANCDTSGLLQIIKTRG--GRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKLTRNLIKG----LK 460

  Fly   520 GVKNLVVKRHNLPVTKIT-EQVMECRSNAETDDYLYLDPKL-LKGGEVLPKNRAPFQDAVVFMVG 582
            ||:| |..:|. |:.|.| |.|.:.|.         |||.. ....|::|..|.| |:.|||::|
  Fly   461 GVEN-VFTQHT-PLLKETLEDVFKGRE---------LDPLFPAINSELVPFRRPP-QEVVVFIIG 513

  Fly   583 GGNYIEYQNLVDFIKQKQTSNVQRRIIYGASTLTNARQFLKELSALGGEIQ 633
            |..|.|      .:...|.:|...::|.|.:|:.|::.|::|:.|....||
  Fly   514 GATYEE------ALAVHQLNNAGYKVILGGTTIHNSQSFIQEVVAATSGIQ 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_001137769.2	Sec1	1..630	CDD:301618	145/631 (23%)
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	140/616 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11679
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940