DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slh and scfd1

DIOPT Version :9

Sequence 1:	NP_001137769.2	Gene:	Slh / 33434	FlyBaseID:	FBgn0264978	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_878281.1	Gene:	scfd1 / 317732	ZFINID:	ZDB-GENE-030116-3	Length:	632	Species:	Danio rerio

Alignment Length:	638	Identity:	372/638 - (58%)
Similarity:	496/638 - (77%)	Gaps:	22/638 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLRERQINAIKQMLNLNSQQPKALAAEPVWKILIYDRVGQDIISPIISIKELRELGVTLHVQLHS 67
            ::||:|..|:|:|||.|:...|...||||||:|||||.|||||||::|:||||::|:|||:.|||
Zfish     4 SIREKQTAALKRMLNFNAPPLKNTTAEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHS 68

  Fly    68 DRDSIPDVPAIYFCLPTDENLDRIQQDFSSGLYDVYHLNFLAPITRSKIENLAAAALHAGCVANI 132
            |||.|||||||||.:||:||:|||.||..:.||:.|:|||::.|:|||:|::|:|||.|..|..:
Zfish    69 DRDPIPDVPAIYFIMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIASAALAANAVNQV 133

  Fly   133 HRVYDQYVNFISLEDDFFILKHQQSDQLSYYAINRANTRDEEMEALMDSIVDSLFALFVTLGNVP 197
            .:|:|||:|||:||||.|||.:|..:.:||:|||:.:..|.:||.:||:||||||..|||||.||
Zfish   134 TKVFDQYLNFITLEDDMFILCNQNKEHISYHAINKPDIMDTDMEGIMDTIVDSLFCFFVTLGAVP 198

  Fly   198 IIRCPRNSAAEMVARKLEKKLRENLWDARANLFHMDATQAGGGVFSFQRPVLLLLDRNMDLATPL 262
            ||||||.:||||||.||:|||||||.|||.:||..|.  .|.|.||||||:.:|.|||:||||||
Zfish   199 IIRCPRGNAAEMVAVKLDKKLRENLRDARNSLFTGDT--MGTGQFSFQRPLFVLADRNLDLATPL 261

  Fly   263 HHTWSYQALVHDVLDLGLNLVYVED----ETASAGAR---KKPKACDLDRNDRFWMTHKGSPFPT 320
            ||||:||||:|||||..||.|.|::    |.:.||||   |..|:.||...|:||..|||||||.
Zfish   262 HHTWTYQALIHDVLDFHLNRVSVDESHGSEASPAGARPKKKNKKSYDLTAADKFWQKHKGSPFPE 326

  Fly   321 VAEAIQEELESYRNSEEEIKRLKTSMGIEGESDIAFSLVNDTTARLTNAVNSLPQLMEKKRLIDM 385
            ||||:||||::||..|:|:||||:.||:|||.|.|.|:::|.||:||:||:|||:|:|||||||:
Zfish   327 VAEAVQEELDTYRAQEDEVKRLKSIMGLEGEDDGAISMLSDNTAKLTSAVSSLPELLEKKRLIDL 391

  Fly   386 HTKIATAILNFIKARRLDSFFEIEEKVMSKQTLDRPLLDLLRDGEFGQAEDKLRLYIIYFICAQQ 450
            ||.:|||:|:.||:|:||.:||.|||:|||.|||:.|||::.|.:.|.||||:||::||:|.:||
Zfish   392 HTNVATAVLDHIKSRKLDVYFEYEEKLMSKSTLDKSLLDIISDPDAGTAEDKMRLFLIYYITSQQ 456

  Fly   451 LP-ESEQERLKEALQAAGCDLTALAYVQRWKGI--MNRSPSISQATQYEGGGTKTVSMFTKLVSQ 512
            .| |::.|:.|:|:..|||||:.|.|:::||..  |..:|:     .|...|.|.:.:|:::::.
Zfish   457 PPSEADLEQYKKAMVDAGCDLSPLNYIKQWKAFTKMAATPA-----NYGSSGVKPMGLFSRVMNT 516

  Fly   513 GSSFVMEGVKNLVVKRHNLPVTKITEQVMECRSNAETDDYLYLDPKLLKGGE-VLPKNRAPFQDA 576
            ||.||||||||||:|:||||||:|.:.:||.:||.|||||.|.|||:|:|.| .:|:|:.|||:|
Zfish   517 GSQFVMEGVKNLVLKQHNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGSESSIPRNKNPFQEA 581

  Fly   577 VVFMVGGGNYIEYQNLVDFIKQKQTSNVQRRIIYGASTLTNARQFLKELSALG 629
            :||:||||||||||||||:.|.:|    .:||:||.|.|.||.||:|:||.||
Zfish   582 IVFVVGGGNYIEYQNLVDYTKTRQ----GKRILYGCSELFNAAQFIKQLSQLG 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_001137769.2	Sec1	1..630	CDD:301618	372/638 (58%)
scfd1	NP_878281.1	Sec1	34..619	CDD:279352	348/595 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574691
Domainoid	1	1.000	706	1.000	Domainoid score	I120
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5650
Inparanoid	1	1.050	743	1.000	Inparanoid score	I568
OMA	1	1.010	-	-		QHG53926
OrthoDB	1	1.010	-	-		D168850at33208
OrthoFinder	1	1.000	-	-		FOG0004255
OrthoInspector	1	1.000	-	-		oto38798
orthoMCL	1	0.900	-	-		OOG6_101825
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1350
SonicParanoid	1	1.000	-	-		X3513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940