DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slh and SCFD1

DIOPT Version :9

Sequence 1:	NP_001137769.2	Gene:	Slh / 33434	FlyBaseID:	FBgn0264978	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_057190.2	Gene:	SCFD1 / 23256	HGNCID:	20726	Length:	642	Species:	Homo sapiens

Alignment Length:	636	Identity:	368/636 - (57%)
Similarity:	485/636 - (76%)	Gaps:	18/636 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLRERQINAIKQMLNLNSQQPKALAAEPVWKILIYDRVGQDIISPIISIKELRELGVTLHVQLHS 67
            ::||||..|:|:|||.|....|....|||||:|||||.|||||||::|:||||::|:|||:.|||
Human    14 SIRERQTVALKRMLNFNVPHIKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHS 78

  Fly    68 DRDSIPDVPAIYFCLPTDENLDRIQQDFSSGLYDVYHLNFLAPITRSKIENLAAAALHAGCVANI 132
            |||.||||||:||.:||:||:||:.||..:.||:.|:|||::.|:|||:|::|.|||.|..|..:
Human    79 DRDPIPDVPAVYFVMPTEENIDRMCQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQV 143

  Fly   133 HRVYDQYVNFISLEDDFFILKHQQSDQLSYYAINRANTRDEEMEALMDSIVDSLFALFVTLGNVP 197
            .:|:|||:|||:||||.|:|.:|..:.:||.||||.:..|.|||.:||:||||||..|||||.||
Human   144 AKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVP 208

  Fly   198 IIRCPRNSAAEMVARKLEKKLRENLWDARANLFHMDATQAGGGVFSFQRPVLLLLDRNMDLATPL 262
            ||||.|.:||||||.||:|||||||.|||.:||..|.  .|.|.||||||:|:|:|||:||||||
Human   209 IIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDT--LGAGQFSFQRPLLVLVDRNIDLATPL 271

  Fly   263 HHTWSYQALVHDVLDLGLNLVYVED----ETASAGA---RKKPKACDLDRNDRFWMTHKGSPFPT 320
            ||||:||||||||||..||.|.:|:    |.:.|||   ||..|:.||...|:||..|||||||.
Human   272 HHTWTYQALVHDVLDFHLNRVNLEESSGVENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPE 336

  Fly   321 VAEAIQEELESYRNSEEEIKRLKTSMGIEGESDIAFSLVNDTTARLTNAVNSLPQLMEKKRLIDM 385
            |||::|:||||||..|:|:||||:.||:|||.:.|.|:::|.||:||:||:|||:|:|||||||:
Human   337 VAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDL 401

  Fly   386 HTKIATAILNFIKARRLDSFFEIEEKVMSKQTLDRPLLDLLRDGEFGQAEDKLRLYIIYFICAQQ 450
            ||.:|||:|..||||:||.:||.|||:|||.|||:.|||::.|.:.|..|||:||::||:|..||
Human   402 HTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISTQQ 466

  Fly   451 LP-ESEQERLKEALQAAGCDLTALAYVQRWKGIMNRSPSISQATQYEGGGTKTVSMFTKLVSQGS 514
            .| |::.|:.|:||..|||:|..|.|:::||.....:   |....|....||.:.:.:::::.||
Human   467 APSEADLEQYKKALTDAGCNLNPLQYIKQWKAFTKMA---SAPASYGSTTTKPMGLLSRVMNTGS 528

  Fly   515 SFVMEGVKNLVVKRHNLPVTKITEQVMECRSNAETDDYLYLDPKLLKGGE-VLPKNRAPFQDAVV 578
            .||||||||||:|:.|||||:|.:.:||.:||.|||||.|.|||:|:|.: .:|:|:.|||:|:|
Human   529 QFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIV 593

  Fly   579 FMVGGGNYIEYQNLVDFIKQKQTSNVQRRIIYGASTLTNARQFLKELSALG 629
            |:||||||||||||||:||.||    .:.|:||.|.|.||.||:|:||.||
Human   594 FVVGGGNYIEYQNLVDYIKGKQ----GKHILYGCSELFNATQFIKQLSQLG 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_001137769.2	Sec1	1..630	CDD:301618	368/636 (58%)
SCFD1	NP_057190.2	Sec1	44..629	CDD:307231	344/593 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141685
Domainoid	1	1.000	693	1.000	Domainoid score	I133
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5650
Inparanoid	1	1.050	727	1.000	Inparanoid score	I619
Isobase	1	0.950	-	0	Normalized mean entropy	S1059
OMA	1	1.010	-	-		QHG53926
OrthoDB	1	1.010	-	-		D168850at33208
OrthoFinder	1	1.000	-	-		FOG0004255
OrthoInspector	1	1.000	-	-		oto90726
orthoMCL	1	0.900	-	-		OOG6_101825
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1350
SonicParanoid	1	1.000	-	-		X3513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890