Protein Alignment Slh and Vps45

DIOPT Version :9

• Sequence 1: NP_001137769.2
• Gene: Slh / 33434
• FlyBaseID: FBgn0264978
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_038869.1
• Gene: Vps45 / 22365
• MGIID: 891965
• Length: 570
• Species: Mus musculus
• Alignment Length: 659
• Identity: 153/659 - (23%)
• Similarity: 275/659 - (41%)
• Gaps: 130/659 - (19%)

  Fly    11 AIKQMLNLNSQQPKALAAEPVWKILIYDRVGQDIISPIISIKELRELGVTLHVQLHS-DRDSIPD 74
            |:||.::...:.     :.|..|:|:.|:....|:|.:.:..|:.:..|.|..::.| :|:.:..
Mouse     6 AVKQYISKMIED-----SGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKH 65

  Fly    75 VPAIYFCLPTDENLDRIQQDFSSGLYDVYHLNFLAPITRSKIENLAAAALHAGCVANIHRVYDQY 139
            :.||.|..||.||::.:.|:.....|.:|.:.|...|::|.:::||.|. ....||.:...|..|
Mouse    66 LKAICFLRPTKENVEYLIQELRRPKYSIYFIYFSNVISKSDVKSLAEAD-EQEVVAEVQEFYGDY 129

  Fly   140 VNFISLEDDFFILKHQQSDQLSYYAINRANTRDEEMEALMDSIVDSLFALFVTLGNVPIIRCPRN 204
               |::....|.|.          .:.....|:.: .|.:......|.||.::|...|:||...:
Mouse   130 ---IAVNPHLFSLN----------ILGCCQGRNWD-PAQLSRTTQGLTALLLSLKKCPMIRYQLS 180

  Fly   205 SAA-----EMVARKLEKKLRENLWDARANLFHMDATQAGGGVFSFQR----PVLLLLDRNMDLAT 260
            |.|     |.|.:.:.|:..                     :|.|:|    |:||:|||..|..|
Mouse   181 SEAAKRLGECVKQVISKEYE---------------------LFEFRRTEVPPLLLILDRCDDAIT 224

  Fly   261 PLHHTWSYQALVHDVLDLGLNLVYVEDETASAGARKKPKACDLD-RNDRFWMTHKGSPFPTVAEA 324
            ||.:.|:|||:||::|.:..|.:   |.:...|..|..:...|. .||.|:..:....|..:...
Mouse   225 PLLNQWTYQAMVHELLGINNNRI---DLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSN 286

  Fly   325 IQEELESYRNSEEEIKRLKTSMGIEGESDI-AFSLVNDTTARLTNAVNSLPQLMEKKRLIDMHTK 388
            |:..:|.::.     ||.|....:|..:|: ||             |.:.||..:....:..|..
Mouse   287 IKNLMEDFQK-----KRPKEQQKLESIADMKAF-------------VENYPQFKKMSGTVSKHVT 333

  Fly   389 IATAILNFIKARRLDSFFEIEEKVMSK-------QTLDRPLLDLLRDGEFGQAEDKLRLYIIYFI 446
            :...:...:..|.|....|:|:::..:       |.:.| ||...:..||    |.:||.::|.:
Mouse   334 VVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNVKR-LLQNPKVTEF----DAVRLVMLYAL 393

  Fly   447 CAQQLPESEQERLKEALQAAGCDLTALAYVQRWKGIMNRSPSISQATQYEGGGTKTVSMF----- 506
                   ..:.....:|.....||.:....::::.:      :|...:|.|...:...:|
Mouse   394 -------HYERHSSNSLPGLIVDLRSKGVAEKYRKL------VSAVVEYGGKRVRGSDLFSPKDA 445

  Fly   507 ---TKLVSQGSSFVMEGVKNLVVKRHNLPVTKITEQVMECRSNAETDDYLYLDPKLLKGGEVLPK 568
               ||...:|    ::||:| |..:|...:.:..:.:::.|  .:.:.|.||.|..|:...
Mouse   446 VAITKQFLKG----LKGVEN-VYTQHQPFLHETLDHLIKGR--LKENLYPYLGPSTLRDRP---- 499

  Fly   569 NRAPFQDAVVFMVGGGNYIEYQNLVDFIKQKQTSNVQRRIIYGASTLTNARQFLKELSALG---G 630
                 ||.:||::||..|.|  .|..:...:.|..|  ||:.|.:|:.|.:.||:|:.|.|   .
Mouse   500 -----QDIIVFIIGGATYEE--ALTVYNLNRTTPGV--RIVLGGTTIHNTKSFLEEVLASGLHSR 555

  Fly   631 EIQSPTATS 639
            ..:|..|||
Mouse   556 SRESSQATS 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_001137769.2	Sec1	1..630	CDD:301618	149/648 (23%)
Vps45	NP_038869.1	Sec1	23..539	CDD:279352	139/610 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910