Protein Alignment Slh and Stxbp3

DIOPT Version :10

• Sequence 1: NP_995614.1
• Gene: Slh / 33434
• FlyBaseID: FBgn0264978
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_035634.1
• Gene: Stxbp3 / 20912
• MGIID: 107362
• Length: 592
• Species: Mus musculus
• Alignment Length: 644
• Identity: 129/644 - (20%)
• Similarity: 251/644 - (38%)
• Gaps: 136/644 - (21%)

  Fly    29 EPVWKILIYDRVGQDIISPIISIKELRELGVTLHVQLHSDRDSIPDVPAIYFCLPTDENLDRIQQ 93
            |..|||::.|.....::|....:.:|.|.|:|:...::.:|:.:..:.|:||..||.:::|...:
Mouse    29 EGEWKIMLLDEFTTKLLSSCCKMTDLLEEGITVIENIYKNREPVRQMKALYFISPTPKSVDCFLR 93

  Fly    94 DFSS-------GLYDVYHLNFLAPITRSKIENLAAAALHAGCVANIHRVYDQYVNFISLEDDFFI 151
            ||.|       ..| :|..:|......:||:        |.|..:|.|..:..::||..|...:.
Mouse    94 DFGSKSEKKYKAAY-IYFTDFCPDSLFNKIK--------ASCSKSIRRCKEINISFIPQESQVYT 149

  Fly   152 LKHQQSDQLSYYAINRANTRDEEMEALMDSIVDSLFALFVTLGNVPIIRC---PRNSAAEMVARK 213
            |   ......||..:...:.....|.:|:::.:.:..:..||...|.:|.   |.::|::: |:.
Mouse   150 L---DVPDAFYYCYSPDPSNASRKEVVMEAMAEQIVTVCATLDENPGVRYKSKPLDNASKL-AQL 210

  Fly   214 LEKKLRENLWDARANLFHMDATQAGGGVFSFQRPVLLLLDRNMDLATPLHHTWSYQALVHDVLDL 278
            :||||.:        .:.:|..   |.:....:..||::||..|..:.:.|..::||:.:|:|.
Mouse   211 VEKKLED--------YYKIDEK---GLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLP- 263

  Fly   279 GLNLVYVEDETASAGARKKPKACDLDRNDRFWMTHKGSPFPTVAEAI---QEELESYRNSEEEIK 340
                  :|::|.......|.|...|:.:|..|:..:......|.|.|   .:|:.|.:.:.|.
Mouse   264 ------IENDTYKYKTDGKEKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEG-- 320

  Fly   341 RLKTSMGIEGESDIAFSLVNDTTARLTNAVNSLPQLMEKKRLIDMHTKIATAILNFIKARRLDSF 405
              |||:                 :.||..:..:|...::.....:|..:|...:|..|
Mouse   321 --KTSL-----------------SALTQLMKKMPHFRKQISKQVVHLNLAEDCMNKFK------- 359

  Fly   406 FEIEEKVMSKQTLDRPLLDLLRDGEFGQAE-------------------DKLRLYIIYFICAQQL 451
            ..||:...::|.     |.|..|.| ||..                   ||:|..::|.......
Mouse   360 LNIEKLCKTEQD-----LALGTDAE-GQRVKDSMLVLLPVLLNKNHDNCDKIRAVLLYIFGINGT 418

  Fly   452 PESEQERLKEALQAA-GCDLTALAYVQRWK--GIMNRSPSISQATQYEGGGTKTVSMFTKLVSQG 513
            .|...:||...::.. ..|:     ::.|.  |:    |.:..:.|.:.......:..|..:|:.
Mouse   419 TEENLDRLIHNVKIEDDSDM-----IRNWSHLGV----PIVPPSQQAKPLRKDRSAEETFQLSRW 474

  Fly   514 SSFVMEGVKNLVVKR---------HNLPVTKITEQVMECRSNAETDDYLYLDPKLLKGGEVLPKN 569
            :.|:.:.:::.:..|         ...|........:..|....| :||.||   .|.|..|
Mouse   475 TPFIKDIMEDAIDNRLDSKEWPYCSRCPAVWNGSGAVSARQKPRT-NYLELD---RKNGSRL--- 532

  Fly   570 RAPFQDAVVFMVGGGNYIEYQNLVDFIKQKQTSNVQRRIIYGASTLTNARQFLKELSAL 628
                   ::|::||..|.|.:...:..:..::..|    |.|::.:...|:.|.::..|
Mouse   533 -------IIFVIGGITYSEMRCAYEVSQAHKSCEV----IIGSTHILTPRKLLDDIKML 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_995614.1	Sec1	33..624	CDD:460020	126/634 (20%)
Stxbp3	NP_035634.1	Mediates interaction with DOC2B. /evidence=ECO:0000269|PubMed:17548353	1..255		56/249 (22%)
		Sec1	33..576	CDD:460020	126/634 (20%)