Protein Alignment Slh and sly-1

DIOPT Version :9

• Sequence 1: NP_001137769.2
• Gene: Slh / 33434
• FlyBaseID: FBgn0264978
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_499317.2
• Gene: sly-1 / 185707
• WormBaseID: WBGene00009654
• Length: 675
• Species: Caenorhabditis elegans
• Alignment Length: 660
• Identity: 294/660 - (44%)
• Similarity: 433/660 - (65%)
• Gaps: 52/660 - (7%)

  Fly     3 TLRERQINAIKQMLNLNSQQPKALAAEPVWKILIYDRVGQDIISPIISIKELRELGVTLHVQLHS 67
            ::|.|||.|::.|:|||.....:...|||||:|:.||.|||||||::.:|:|||||||||:.:.:
 Worm     7 SVRTRQIVALRTMINLNEPVVNSGVREPVWKVLVLDRTGQDIISPLLPVKQLRELGVTLHLLIGA 71

  Fly    68 DRDSIPDVPAIYFCLPTDENLDRIQQDFSSGLYDVYHLNFLAPITRSKIENLAAAALHAGCVANI 132
            .|:.:.||||:||..|.|||:|.:.:|....:||.::.||::|:.|.::|:||:||:|.|.|:.:
 Worm    72 RREPLTDVPAVYFVSPNDENIDLMSEDLKKAMYDSFYCNFISPLARPRLESLASAAVHGGAVSQV 136

  Fly   133 HRVYDQYVNFISLEDDFFIL-KHQQSDQLSYYAINRANTRDEEMEALMDSIVDSLFALFVTLGNV 196
            .:|.|||:||||||||.|:| ::.::...||:|:|...|.|..:.|::|||.|.|||:..|:|.|
 Worm   137 QKVVDQYLNFISLEDDLFVLRRYSENSTFSYHAMNSPGTSDVAVNAMLDSIADGLFAVCATMGIV 201

  Fly   197 PIIRCPRNSAAEMVARKLEKKLRENLWDARANLFHMDATQAGGGVFSFQRPVLLLLDRNMDLATP 261
            ||||||:.:||||||:||::|||:||.|:|.|||.||..:.  |:....||:|::.||:.||||.
 Worm   202 PIIRCPKGNAAEMVAKKLDQKLRDNLRDSRNNLFTMDGVRM--GLLQTSRPLLVIGDRSADLATM 264

  Fly   262 LHHTWSYQALVHDVLDLGLNLVYVEDETASAGARKKPKACDLDR----NDRFWMTHKGSPFPTVA 322
            |||||:||||:||||:|..|.|.:  .|:|.|.:|     |.|.    :|:.|..||||.|||||
 Worm   265 LHHTWTYQALMHDVLELDQNRVTI--STSSTGKKK-----DYDMATGGSDKLWNNHKGSAFPTVA 322

  Fly   323 EAIQEELESYRNSEEEIKRLKTSMGIEGESDIA----FSLVNDTTARLTNAVNSLPQLMEKKRLI 383
            ||:||.|:.||:.|::||::|.::|:.|||:.|    .:::.||||:|.:.|.|||.|:|.||||
 Worm   323 EAVQENLDDYRSKEDDIKKIKQALGLSGESEAADEALTNVLADTTAKLGSTVMSLPDLLESKRLI 387

  Fly   384 DMHTKIATAILNFIKARRLDSFFEIEEKVMSKQTLDRPLLDLLRDGEFGQAEDKLRLYIIYFICA 448
            |:||.|||.:|:.||.|:||..||:|:|::....||:|:...|  ......||.||:.||.|:|.
 Worm   388 DLHTNIATTLLDVIKERKLDVLFELEQKLLQHSPLDQPVTQFL--SNINHQEDVLRVLIIAFLCQ 450

  Fly   449 QQLPESEQERLKEALQAAGCDLTALAYVQRWKGIM---NRSPSISQATQYEGGGTKTVSMFTKLV 510
            :.:.::..:::...|:..|.:.:||.:||:.|.|.   :|:.:.:...:::|.||||:|||.||:
 Worm   451 ETVNQNGYDQMMNLLRERGIEESALKHVQKLKSISQLGSRAANSAHTEEHQGAGTKTISMFGKLL 515

  Fly   511 SQGSSFVMEGVKNLVVKRHNLPVTK-------------------ITEQVMECRSNAETDD-YLYL 555
            |..|.||||||||||.|.||||:||                   |.:.:.......:.|| |.:.
 Worm   516 SHSSKFVMEGVKNLVPKEHNLPLTKMIDSLNTPPSSTGISSAVGINQMIGGSSQGPDIDDIYCFF 580

  Fly   556 DPKLL----KGGEVLPKNRAPFQDAVVFMVGGGNYIEYQNLVDFIKQKQTSNVQRRIIYGASTLT 616
            ||||:    |...:|.:.::. ||.::|:||||||:|||||||:.|:|..    .|:.||.:.|.
 Worm   581 DPKLMHQPTKETILLARQQSA-QDVILFVVGGGNYVEYQNLVDYGKRKNL----MRVTYGCTELV 640

  Fly   617 NARQFLKELS 626
            |..||..::|
 Worm   641 NPAQFCDQVS 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slh	NP_001137769.2	Sec1	1..630	CDD:301618	294/660 (45%)
sly-1	NP_499317.2	Sec1	7..650	CDD:301618	293/658 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156577
Domainoid	1	1.000	527	1.000	Domainoid score	I142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5650
Inparanoid	1	1.050	554	1.000	Inparanoid score	I604
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53926
OrthoDB	1	1.010	-	-		D168850at33208
OrthoFinder	1	1.000	-	-		FOG0004255
OrthoInspector	1	1.000	-	-		oto18912
orthoMCL	1	0.900	-	-		OOG6_101825
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1350
SonicParanoid	1	1.000	-	-		X3513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940