Protein Alignment dpp and GDF15

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_004855.2
• Gene: GDF15 / 9518
• HGNCID: 30142
• Length: 308
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 87/362 - (24%)
• Similarity: 132/362 - (36%)
• Gaps: 93/362 - (25%)

  Fly   262 GHELDSVN-------------IPKPGLLTKSANTVRSF-----THKDSKIDDRFPHHHRFRLHFD 308
            |.||.:||             :|..|.|:.:..:..||     .|.:..         |||
Human     3 GQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDS---------RFR---- 54

  Fly   309 VKSIPADEKLKAAELQLTRDALSQQVVASRSS-ANRTRYQVLVYDITRVGVRGQRE--------- 363
                   |..|..|..|||...:|....|.:. ......::|..:: |:|..|...
Human    55 -------ELRKRYEDLLTRLRANQSWEDSNTDLVPAPAVRILTPEV-RLGSGGHLHLRISRAALP 111

  Fly   364 ---PSYLLLDTKTVRLNSTDTVSLDVQPAVDRW--LASPQRNYGLLVEVRTVRSLKPAPHHHVRL 423
               |....|.....||:.|.:.|.||...:.|.  ||.||   ...:.:|    |.|.|....:|
Human   112 EGLPEASRLHRALFRLSPTASRSWDVTRPLRRQLSLARPQ---APALHLR----LSPPPSQSDQL 169

  Fly   424 RRSADEAHERWQ-HKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRN-KRQPRRPTRRKNHDDT 486
            ...:..|..:.: |.:|    ....||.:||:              || ...|..|.|      .
Human   170 LAESSSARPQLELHLRP----QAARGRRRARA--------------RNGDHCPLGPGR------C 210

  Fly   487 CRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTN-HAVVQTLVNNMNPGKVPK 550
            ||.|::.....|:||.||:::|.......|.|.||    ..|.:.| ||.::|.::.:.|..||.
Human   211 CRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP----SQFRAANMHAQIKTSLHRLKPDTVPA 271

  Fly   551 ACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587
            .||||...:.:.::...| :.|.|:.|.::....|.|
Human   272 PCCVPASYNPMVLIQKTD-TGVSLQTYDDLLAKDCHC 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	47/215 (22%)
		TGFB	487..588	CDD:214556	31/102 (30%)
GDF15	NP_004855.2	MscS_TM	<23..>147	CDD:331130	30/144 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..177		5/28 (18%)
		TGFB	211..308	CDD:214556	31/102 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810