Protein Alignment dpp and GDF5

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_000548.2
• Gene: GDF5 / 8200
• HGNCID: 4220
• Length: 501
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 155/619 - (25%)
• Similarity: 234/619 - (37%)
• Gaps: 165/619 - (26%)

  Fly     3 AWLLLLAVLATFQTIVRVASTEDISQRFIAAIAPVAAHIPLASASGS-------GSGRSGSRSVG 60
            |||.|       :.|..|....|:.||      |......||.|...       ...|.|..|.|
Human    15 AWLDL-------EFICTVLGAPDLGQR------PQGTRPGLAKAEAKERPPLARNVFRPGGHSYG 66

  Fly    61 ASTSTALAKAFNPFSEPASFSDSDKSHRSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNKSKQL 125
            ...:.|.|:|.....:....:...|....|...:|...:.
Human    67 GGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEP------------------------- 106

  Fly   126 VNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESHQSSSIESIFVEEPTLVLDREVASINV 190
              ||.|                   ..|.:||:|.|.:.:.                 ::.....
Human   107 --KPGH-------------------PPQTRQATARTVTPKG-----------------QLPGGKA 133

  Fly   191 PANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIP-EPMK 254
            |..|.::     ||::    |:|...:|.|.               :.|.:..|...|.| |.|.
Human   134 PPKAGSV-----PSSF----LLKKAREPGPP---------------REPKEPFRPPPITPHEYML 174

  Fly   255 KLYAEIMGHEL----DSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPAD 315
            .||..:...:.    .||.: :.||    |||:.||..|..  |||.|...:.|..||:.::..|
Human   175 SLYRTLSDADRKGGNSSVKL-EAGL----ANTITSFIDKGQ--DDRGPVVRKQRYVFDISALEKD 232

  Fly   316 EKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTV-RLNST 379
             .|..|||::.|...|.....:.....|..      .:........|:|: .|||.::| .|:.:
Human   233 -GLLGAELRILRKKPSDTAKPAAPGGGRAA------QLKLSSCPSGRQPA-ALLDVRSVPGLDGS 289

  Fly   380 DTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTY 444
            .....|:......:..|.|    |.:|:......:......:...|:|.:.||:     .|...:
Human   290 GWEVFDIWKLFRNFKNSAQ----LCLELEAWERGRAVDLRGLGFDRAARQVHEK-----ALFLVF 345

  Fly   445 TDDGRHKARSIRDVSGGEGGGKGGRN--------------------KRQPRRPTRRKNHDDTCRR 489
               ||.|.   ||:...|...:.|::                    .||.:||:  ||....|.|
Human   346 ---GRTKK---RDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPS--KNLKARCSR 402

  Fly   490 HSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCV 554
            .:|:|:|.|:||||||:|||.|:|::|.|.|.|||..|...|||||:|||:|:|:|...|..|||
Human   403 KALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCV 467

  Fly   555 PTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
            ||:|..:::|:::..:.||.|.|::|.|..||||
Human   468 PTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	50/224 (22%)
		TGFB	487..588	CDD:214556	51/100 (51%)
GDF5	NP_000548.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..169		36/232 (16%)
		TGFb_propeptide	145..344	CDD:279078	54/237 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..265		2/24 (8%)
		TGFB	400..501	CDD:214556	51/100 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810