Protein Alignment dpp and Tgfb2

DIOPT Version :10

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_112393.2
• Gene: Tgfb2 / 81809
• RGDID: 70491
• Length: 442
• Species: Rattus norvegicus
• Alignment Length: 432
• Identity: 108/432 - (25%)
• Similarity: 171/432 - (39%)
• Gaps: 90/432 - (20%)

  Fly   212 IKDKLK--------PDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYA---------E 259
            |..|||        |:|.   |:...::|::|..|.        ::.|...:..|         |
  Rat    44 ILSKLKLTSPPEDYPEPD---EVPPEVISIYNSTRD--------LLQEKASRRAAACERERSDEE 97

  Fly   260 IMGHELDSVNIPK--PG-----LLTKSANTVRSFTHKDSKI-----DDRFPHHHR--FRL-HFDV 309
            ....|:..:::|.  |.     ::|.|:.:|.||..:.|::     |...|..:|  ||: .|||
  Rat    98 YYAKEVYKIDMPSHFPSETVCPVVTTSSGSVGSFCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDV 162

  Fly   310 KSIPAD-EKLKAAELQLTRDALSQQVVASRSSANRTR-YQVL-VYDITRVGVRGQREPSYLLLDT 371
            .::..: ..|..||.::.|    .|...:|.:..|.. ||:| ..|:|        .|:...:|:
  Rat   163 STMEKNASNLVKAEFRVFR----LQNPKARVAEQRIELYQILKSKDLT--------SPTQRYIDS 215

  Fly   372 KTVRLNST-DTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPA----PHHHVRLRRSADEAH 431
            |.|:..:. :.:|.||..||..||....||.|..:.:..     |.    |.::..:...:.|..
  Rat   216 KVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHC-----PCCTFIPSNNYIIPNKSQELE 275

  Fly   432 ERWQHKQPLLFTYTDDGRHKARSIRDVSGG---------------EGGGKGGRNKRQPRRPTRRK 481
            .|:..... ..||....:...:|.|..|.|               |......|.||........:
  Rat   276 ARFAGIDG-TSTYASGDQKTIKSTRKKSSGKTPHLLLMLLPSYRLESQQSSRRRKRALDAAYCFR 339

  Fly   482 NHDDTCRRHSLYVDFS-DVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNP 545
            |..|.|....||:||. |:|| .||..|.||:|.:|.|.||:..:   :.|.|..|.:|.|.:||
  Rat   340 NVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWS---SDTQHTKVLSLYNTINP 400

  Fly   546 GKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587
            ......|||...|:.:.:||... :|..::....|.|..|.|
  Rat   401 EASASPCCVSQDLEPLTILYYIG-NTPKIEQLSNMIVKSCKC 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	54/250 (22%)
		TGF_beta_DPP	480..588	CDD:381662	38/109 (35%)
Tgfb2	NP_112393.2	TGFb_propeptide	21..256	CDD:459906	56/239 (23%)
		TGF_beta_TGFB2	345..441	CDD:381655	35/100 (35%)