Protein Alignment dpp and LEFTY2

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_003231.2
• Gene: LEFTY2 / 7044
• HGNCID: 3122
• Length: 366
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 88/408 - (21%)
• Similarity: 139/408 - (34%)
• Gaps: 133/408 - (32%)

  Fly   229 SLLSLFNMKRPPKIDRS---KIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKD 290
            |||....:...|.:||:   |::||..::..|..               ||.:|        |.|
Human    30 SLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYVV---------------LLRRS--------HGD 71

  Fly   291 SKIDDRFPHHHR-------------FRLHFDVKS-IPADEKLKAAELQLTRDALSQQV------V 335
            .....||....|             ..|.|.::. :|.:.:|..|.|:|.::.:.:..      :
Human    72 RSRGKRFSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRL 136

  Fly   336 ASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRN 400
            :.||:..|...:.|     ||...|....|  |:|::.|.::.:...:.||..||:.|....:..
Human   137 SPRSAQARVTVEWL-----RVRDDGSNRTS--LIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPR 194

  Fly   401 YGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGG 465
            ..||::|...|                       :|..||.     .|.||.  :|..|.|...|
Human   195 QPLLLQVSVQR-----------------------EHLGPLA-----SGAHKL--VRFASQGAPAG 229

  Fly   466 ---------------KGGRNKRQPRRP----TRRKNHDDTCRRHSLYVDFSDVGW-DDWIVAPLG 510
                           .|.:....|..|    ||       |.|..:|:|...:.| .:|::.|.|
Human   230 LGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTR-------CCRQEMYIDLQGMKWAKNWVLEPPG 287

  Fly   511 YDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQ------ 569
            :.||.|.|.|..|            .:.|..|. |...|:. |:.::..|:.|:....:
Human   288 FLAYECVGTCQQP------------PEALAFNW-PFLGPRQ-CIASETASLPMIVSIKEGGRTRP 338

  Fly   570 STVVLKNYQEMTVVGCGC 587
            ..|.|.|   |.|..|.|
Human   339 QVVSLPN---MRVQKCSC 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	48/237 (20%)
		TGFB	487..588	CDD:214556	28/108 (26%)
LEFTY2	NP_003231.2	TGFb_propeptide	<106..214	CDD:307025	28/142 (20%)
		TGF_beta	263..353	CDD:306518	27/106 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810