Protein Alignment dpp and TGFB3

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001316868.1
• Gene: TGFB3 / 7043
• HGNCID: 11769
• Length: 412
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 99/440 - (22%)
• Similarity: 152/440 - (34%)
• Gaps: 139/440 - (31%)

  Fly   212 IKDKLK----PDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPK 272
            |..||:    |:|:.:..:...:|:|:|..|                :|..|:.|...:...
Human    47 ILSKLRLTSPPEPTVMTHVPYQVLALYNSTR----------------ELLEEMHGEREEGCT--- 92

  Fly   273 PGLLTKSANTVRSF----THKDSKIDDRFPHHHR-----------FRLHFDVKSIPADE-KLKAA 321
                  ..||...:    .||...|.....|:..           ||  |:|.|:..:. .|..|
Human    93 ------QENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFR--FNVSSVEKNRTNLFRA 149

  Fly   322 ELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVG--VRGQREPSYLLLDTKTVRLNSTDTVSL 384
            |.::.|        ....|:.|...::.::.|.|..  :..||......|.|:    .:.:.:|.
Human   150 EFRVLR--------VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSF 202

  Fly   385 DVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGR 449
            ||...|..||...:.|.||.:.:.       .|.|                       |:..:|.
Human   203 DVTDTVREWLLRRESNLGLEISIH-------CPCH-----------------------TFQPNGD 237

  Fly   450 -----HKARSIR----DVSGGEGGGKGGRNKRQ--------------------PRRPTRRK---- 481
                 |:...|:    |.....|.|..||.|:|                    |.:..:||
Human   238 ILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302

  Fly   482 -------NHDDTCRRHSLYVDF-SDVGWDDWIVAPLGYDAYYCHGKCPF-PLADHFNSTNHAVVQ 537
                   |.::.|....||:|| .|:|| .|:..|.||.|.:|.|.||: ..||    |.|:.|.
Human   303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSAD----TTHSTVL 362

  Fly   538 TLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587
            .|.|.:||......||||..|:.:.:||...: |..::....|.|..|.|
Human   363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGR-TPKVEQLSNMVVKSCKC 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	41/236 (17%)
		TGFB	487..588	CDD:214556	38/103 (37%)
TGFB3	NP_001316868.1	TGFb_propeptide	24..230	CDD:395559	45/228 (20%)
		Cell attachment site. /evidence=ECO:0000250|UniProtKB:P01137	261..263		0/1 (0%)
		TGF_beta_TGFB3	312..412	CDD:381656	38/106 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810