Protein Alignment dpp and TGFB1

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: XP_011525544.1
• Gene: TGFB1 / 7040
• HGNCID: 11766
• Length: 391
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 104/459 - (22%)
• Similarity: 163/459 - (35%)
• Gaps: 137/459 - (29%)

  Fly   167 SSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLL 231
            |:.::|.:|   ||..:.:.:|.....:|..:|.. ||        :.::.|.|     :.:::|
Human    31 STCKTIDME---LVKRKRIEAIRGQILSKLRLASP-PS--------QGEVPPGP-----LPEAVL 78

  Fly   232 SLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDR 296
            :|:|..|......|....|||....||:    |:..|      |:.::.|          :|.|:
Human    79 ALYNSTRDRVAGESAEPEPEPEADYYAK----EVTRV------LMVETHN----------EIYDK 123

  Fly   297 FPHH-HRFRLHFDV----KSIPADEKLKAAELQLTRDAL--SQQV-VASRSSANRTRYQVLVYDI 353
            |... |...:.|:.    :::|....|..|||:|.|..|  .|.| :..:.|.|..||
Human   124 FKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRY------- 181

  Fly   354 TRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPH 418
                          |.:......:|.:.:|.||...|.:||:......|.
Human   182 --------------LSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGF--------------- 217

  Fly   419 HHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGG-----RNKRQP---- 474
               ||     .||            .:.|.|.....: |::.|...|:.|     ....:|
Human   218 ---RL-----SAH------------CSCDSRDNTLQV-DINAGFTTGRRGDLATIHGMNRPFLLL 261

  Fly   475 -RRPTRRKNH-------------------DDTCRRHSLYVDF-SDVGWDDWIVAPLGYDAYYCHG 518
             ..|..|..|                   :..|....||:|| .|:|| .||..|.||.|.:|.|
Human   262 MATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGW-KWIHEPKGYHANFCLG 325

  Fly   519 KCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVV 583
            .||:..:   ..|.::.|..|.|..|||.....||||..|:.:.::|...:...| :....|.|.
Human   326 PCPYIWS---LDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVR 386

  Fly   584 GCGC 587
            .|.|
Human   387 SCKC 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	46/226 (20%)
		TGFB	487..588	CDD:214556	36/102 (35%)
TGFB1	XP_011525544.1	TGFb_propeptide	30..262	CDD:395559	65/324 (20%)
		TGF_beta_TGFB1	293..391	CDD:381654	36/103 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810