DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpp and BMP7

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001710.1	Gene:	BMP7 / 655	HGNCID:	1074	Length:	431	Species:	Homo sapiens

Alignment Length:	500	Identity:	135/500 - (27%)
Similarity:	206/500 - (41%)	Gaps:	155/500 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 HNKMAVKEQRSHHKK-------SHHHRSH-QPKQASASTESHQSSSIESIFVEEPTLVLDREVAS 187
            |.::..:|:|...::       .|..|.| |.|..||                 |..:||.
Human    43 HRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSA-----------------PMFMLDL---- 86

  Fly   188 INVPANAKAIIAEQGPS----TYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPP--KIDRSK 246
                .||.|:....||.    :|..:|                      :|:.:.||  .:..|.
Human    87 ----YNAMAVEEGGGPGGQGFSYPYKA----------------------VFSTQGPPLASLQDSH 125

  Fly   247 IIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKS 311
            .:....|...:..::.|:                   :.|.|      .|: ||..||  ||:..
Human   126 FLTDADMVMSFVNLVEHD-------------------KEFFH------PRY-HHREFR--FDLSK 162

  Fly   312 IPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITR--VGVRGQREPSYLLLDTKTV 374
            ||..|.:.|||.::.:|.:       |...:...:::.||.:.:  :|    ||....|||::|:
Human   163 IPEGEAVTAAEFRIYKDYI-------RERFDNETFRISVYQVLQEHLG----RESDLFLLDSRTL 216

  Fly   375 RLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTV--RSLKP---------APHHHVRLRRSAD 428
            ..:....:..|:....:.|:.:|:.|.||.:.|.|:  :|:.|         .|
Human   217 WASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGP----------- 270

  Fly   429 EAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHD--------- 484
                  |:|||.:..:........||||..         |..:|...|....||.:
Human   271 ------QNKQPFMVAFFKATEVHFRSIRST---------GSKQRSQNRSKTPKNQEALRMANVAE 320

  Fly   485 -------DTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNN 542
                   ..|::|.|||.|.|:||.|||:||.||.||||.|:|.|||..:.|:||||:|||||:.
Human   321 NSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHF 385

  Fly   543 MNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587
            :||..|||.||.||||:::::||.:|.|.|:||.|:.|.|..|||
Human   386 INPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	47/233 (20%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	58/100 (58%)
BMP7	NP_001710.1	TGFb_propeptide	35..280	CDD:366248	67/339 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..311		7/28 (25%)
		TGF_beta_BMP7	325..431	CDD:381667	58/105 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820