Protein Alignment dpp and BMP5

DIOPT Version :10

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_066551.1
• Gene: BMP5 / 653
• HGNCID: 1072
• Length: 454
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 132/500 - (26%)
• Similarity: 208/500 - (41%)
• Gaps: 124/500 - (24%)

  Fly   131 HNKMAVKEQRSHHKKS------------HHHRSHQP-KQASASTESHQSSSIESIFVEEPTLVLD 182
            |:....:..|:|.::.            |..|...| ||||::                |..:||
Human    35 HSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSA----------------PLFMLD 83

  Fly   183 REVASINVPANAKAIIAEQGP--STYSKEALIKDKLK-------PDPSTLV-EIEKSLLSLFNMK 237
            ...|..|          |:.|  |.||..|.:.::.:       ..|:... .|:.|..:....:
Human    84 LYNAMTN----------EENPEESEYSVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQ 138

  Fly   238 RPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTH---KDSKIDDRFPH 299
            .||                .|.:  |:.:.:|         .|:.|.||.:   :|.....:..|
Human   139 SPP----------------LASL--HDTNFLN---------DADMVMSFVNLVERDKDFSHQRRH 176

  Fly   300 HHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREP 364
            :..||  ||:..||..|.:.|||.::.:|       .|.:.......::.:|.|.:...  .|:.
Human   177 YKEFR--FDLTQIPHGEAVTAAEFRIYKD-------RSNNRFENETIKISIYQIIKEYT--NRDA 230

  Fly   365 SYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADE 429
            ...||||:..:......:..|:....:.|:.:||.|.||.:...|      .....:.::.:...
Human   231 DLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAET------GDGRSINVKSAGLV 289

  Fly   430 AHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDT-------- 486
            ..:..|.|||.:..:........||:|           ..|||:.:...:..:|.|:
Human   290 GRQGPQSKQPFMVAFFKASEVLLRSVR-----------AANKRKNQNRNKSSSHQDSSRMSSVGD 343

  Fly   487 ---------CRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNN 542
                     |::|.|||.|.|:||.|||:||.||.|:||.|:|.|||..|.|:||||:|||||:.
Human   344 YNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHL 408

  Fly   543 MNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587
            |.|..|||.||.||:|:::::||.:|.|.|:||.|:.|.|..|||
Human   409 MFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	44/221 (20%)
		TGF_beta_DPP	480..588	CDD:381662	59/124 (48%)
BMP5	NP_066551.1	TGFb_propeptide	32..304	CDD:459906	66/338 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..343		5/24 (21%)
		TGF_beta_BMP5	342..454	CDD:381665	57/111 (51%)