Protein Alignment dpp and BMP4

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001334841.1
• Gene: BMP4 / 652
• HGNCID: 1071
• Length: 455
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 167/411 - (40%)
• Similarity: 233/411 - (56%)
• Gaps: 41/411 - (9%)

  Fly   190 VPANAKAIIAE-QGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPM 253
            :|...|..:|| ||.:...:.....:.|:       :.|.:||.:|.::|.|:..:| .:||:.|
Human    74 IPETGKKKVAEIQGHAGGRRSGQSHELLR-------DFEATLLQMFGLRRRPQPSKS-AVIPDYM 130

  Fly   254 KKLYAEIMGHE----LDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFP---HHHRFRLHFDVKS 311
            :.||....|.|    :.|..:..|......|||||||.|::..  :..|   .:..||..|::.|
Human   131 RDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHL--ENIPGTSENSAFRFLFNLSS 193

  Fly   312 IPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYL---LLDTKT 373
            ||.:|.:.:|||:|.|:.:.|     .....|..:::.:|::.:  ...:..|.:|   ||||:.
Human   194 IPENEVISSAELRLFREQVDQ-----GPDWERGFHRINIYEVMK--PPAEVVPGHLITRLLDTRL 251

  Fly   374 VRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQ 438
            |..|.|...:.||.|||.||....|.||||.:||..:...:.....|||:.||..:....|...:
Human   252 VHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLR 316

  Fly   439 PLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRR-KNHDDTCRRHSLYVDFSDVGWD 502
            |||.|:..|||..|.:.|           .|.||.|:..::| :..:..|||||||||||||||:
Human   317 PLLVTFGHDGRGHALTRR-----------RRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWN 370

  Fly   503 DWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLN 567
            ||||||.||.|:||||.||||||||.||||||:||||||::| ..:||||||||:|.:::||||:
Human   371 DWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN-SSIPKACCVPTELSAISMLYLD 434

  Fly   568 DQSTVVLKNYQEMTVVGCGCR 588
            :...|||||||||.|.|||||
Human   435 EYDKVVLKNYQEMVVEGCGCR 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	72/228 (32%)
		TGFB	487..588	CDD:214556	75/100 (75%)
BMP4	NP_001334841.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3626
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2898
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002405
OrthoInspector	1	1.000	-	-		otm40783
orthoMCL	1	0.900	-	-		OOG6_105711
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3241
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.890