Protein Alignment dpp and BMP3

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001192.4
• Gene: BMP3 / 651
• HGNCID: 1070
• Length: 472
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 106/435 - (24%)
• Similarity: 169/435 - (38%)
• Gaps: 113/435 - (25%)

  Fly   249 IPEPMKKLY--------AEIMGHELDSVNIP-KPGLLTKSANTVRSFTHKDSKIDDR-------- 296
            :.|.|.:||        |...| .|:..:.| :|.|| :..||||||....::..:|
Human    56 VSEHMLRLYDRYSTVQAARTPG-SLEGGSQPWRPRLL-REGNTVRSFRAAAAETLERKGLYIFNL 118

  Fly   297 ---------------------------FP-----HHHRFRLHFDVKSIPADEKLKAAELQLT--- 326
                                       .|     .||..|.|..:.......|....:.||.
Human   119 TSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHL 183

  Fly   327 --------RDA---LSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPS--------YLLLDTK 372
                    ||.   ||:.:......|......::.::||.   :|::.|.        |:|:...
Human   184 SVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITS---KGRQLPKRRLPFPEPYILVYAN 245

  Fly   373 TVRLNSTDTVSLDVQ-------PAVDRWLASPQRNYGLLVEVRTVRS---LKPAPHHHVRLRRSA 427
            ...::..::|...:|       ..|.:|  .......|.:|.|..||   |.|..::.:......
Human   246 DAAISEPESVVSSLQGHRNFPTGTVPKW--DSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQ 308

  Fly   428 DEAHERWQHKQP---LLFTYTDDGRHKARSIRDVSGGEGGGKGGRNK-------RQPRRPTRRKN 482
            .:..|.|:.::|   |.....:..::|.:.          .||...|       .|..:..|||.
Human   309 YKKDEVWEERKPYKTLQAQAPEKSKNKKKQ----------RKGPHRKSQTLQFDEQTLKKARRKQ 363

  Fly   483 --HDDTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMN- 544
              ....|.|..|.|||:|:||.:||::|..:|||||.|.|.||:......:|||.:|::|..:.
Human   364 WIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGV 428

  Fly   545 -PGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
             || :|:.||||.::.|:::|:.::...||||.|..|||..|.||
Human   429 VPG-IPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	52/278 (19%)
		TGFB	487..588	CDD:214556	44/102 (43%)
BMP3	NP_001192.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..53
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..350		6/39 (15%)
		TGF_beta_BMP3	363..472	CDD:381663	44/109 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810