DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpp and Gdf9

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_067704.1	Gene:	Gdf9 / 59304	RGDID:	71038	Length:	440	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	106/492 - (21%)
Similarity:	173/492 - (35%)	Gaps:	136/492 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 ASASTESHQSSSIESIFVE-EP---TLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLK 217
            :.|||...|:.:.|::..| :|   .|.:|....|..:|...| :::::...|        .||:
  Rat    25 SQASTGESQAGASENLESEADPWSLLLPVDGTDRSGLLPPLFK-VLSDRRSET--------PKLQ 80

  Fly   218 PDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANT 282
            ||...|..                           |||||......|    .:|||. .:...||
  Rat    81 PDSRALYY---------------------------MKKLYKTYATKE----GVPKPS-RSHLYNT 113

  Fly   283 VRSFTHKDSKIDDRFPHHH------RFRLHFDVKSIPADEKLKAAELQLTR-------------- 327
            ||.|:  .....::.|.:.      ...|.|::..:.|.|.|..:.|..|.
  Rat   114 VRLFS--PCAQQEQAPSNQMTGPLPMVDLLFNLDRVTAMEHLLKSVLLYTLNNSAASSSTVTCVC 176

  Fly   328 DALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDR 392
            |.:.::.::|..:..|..|                  |:.|...:.:.:   |..|| :||.|
  Rat   177 DLVVKEPMSSSKATPRAPY------------------SFTLRKHRWIEM---DVTSL-LQPLV-- 217

  Fly   393 WLASPQRNYGLLVEVRTVRSLKP-----------APHHHVRLRRSADEAHERWQHKQPLLFTYTD 446
              ||.:|:..|.|.....|...|           .|...:.|..::.:|:..||..|       .
  Rat   218 --ASSERSIHLSVNFTCTRDQAPENGTFNMPLSVPPSLILYLNDTSTQAYHSWQSLQ-------S 273

  Fly   447 DGRHKARSIRD-VSGGEGGGKGGRNKRQPRRPTRRKN------------------------HDDT 486
            ..||.....:| |:......:....:|.||....:|.                        ..:.
  Rat   274 TQRHSQHPGQDSVTTRPVEEEATEVERSPRHRRGQKTLSSETKKPLTASFNLSEYFRQFLFPQNE 338

  Fly   487 CRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKA 551
            |..|...:.||.:.||:|||||..|:..||.|.||..:...:.|..|.:||.::.......||:.
  Rat   339 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVRHRYGSPVHTMVQNIIYEKLDPSVPRP 403

  Fly   552 CCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
            .|||.:...:::|.:....::..|.|::|....|.||
  Rat   404 SCVPGKYSPLSVLTIEPDGSIAYKEYEDMIATRCTCR 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	47/249 (19%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	31/100 (31%)
Gdf9	NP_067704.1	TGF_beta	337..439	CDD:278448	31/101 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810