DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpp and GDF6

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001001557.1	Gene:	GDF6 / 392255	HGNCID:	4221	Length:	455	Species:	Homo sapiens

Alignment Length:	411	Identity:	123/411 - (29%)
Similarity:	172/411 - (41%)	Gaps:	97/411 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 KRPPKIDRSKIIIP-EPMKKLY-----AEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDD 295
            :.||  .|...::| |.|..:|     ||.:|.......      .:|||||:.||.  |..:||
Human    83 QEPP--GRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQ------SSKSANTITSFV--DRGLDD 137

  Fly   296 RFPHH--HRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGV 358
             ..|.  .|.:..|||..:...|:|..|||:|.|.|.|..........:...:..|
Human   138 -LSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCL--------- 192

  Fly   359 RGQREPSYLLLDTKTVRLNSTDTVSLDVQPA-------VDRWLA---SPQRNYGLLVEVRT---- 409
                  |.||||.:|          ||.|.|       .|.|..   .|.:.  |.:|:|.
Human   193 ------SPLLLDART----------LDPQGAPPAGWEVFDVWQGLRHQPWKQ--LCLELRAAWGE 239

  Fly   410 -------VRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHK--ARSIRDVSGGEGGG 465
                   .|:..|.......||........|...::.||..:|...|..  |.....:...|..|
Human   240 LDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSAEAAG 304

  Fly   466 KG-----------------------GRNKRQPRRPTRR-KNHDD----TCRRHSLYVDFSDVGWD 502
            .|                       ||.:|:....:|. |.|..    .|.:..|:|:|.::|||
Human   305 PGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWD 369

  Fly   503 DWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLN 567
            |||:|||.|:||:|.|.|.|||..|...||||::|||:|:|:||..|.:|||||:|..:::||::
Human   370 DWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYID 434

  Fly   568 DQSTVVLKNYQEMTVVGCGCR 588
            ..:.||.|.|::|.|..||||
Human   435 AGNNVVYKQYEDMVVESCGCR 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	58/235 (25%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	51/100 (51%)
GDF6	NP_001001557.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..93		3/11 (27%)
		TGFb_propeptide	79..281	CDD:395559	58/235 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..267		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..351		9/50 (18%)
		TGF_beta_GDF5_6_7	354..455	CDD:381644	51/100 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810