Protein Alignment dpp and INHBA

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: XP_016867663.1
• Gene: INHBA / 3624
• HGNCID: 6066
• Length: 548
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 138/632 - (21%)
• Similarity: 224/632 - (35%)
• Gaps: 196/632 - (31%)

  Fly    41 IPLASASGSGSG------RSGSRSVGASTSTALAKAFNPFSEPASFSDSDKSHRSKTNKKPSKSD 99
            :.||.|.|...|      ..|||...:....|.|...:|:..||..:..:...|.:..|.|.|.
Human    27 VALAGAQGKNRGCRLDRLGPGSRHPASWARAAAAFRRDPWKLPAGAAQENLLKRRRKKKTPKKK- 90

  Fly   100 ANRQFNEVHKPRTDQLENSKNKSKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESH 164
                                      :.|..|.|...:|...        ::...|:|..:|.:.
Human    91 --------------------------IKKSTHTKKPAREGGG--------KAGPFKKAITTTFAA 121

  Fly   165 QS----------SSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPD 219
            :.          :|...|....||...:...|:.:.|:.|.|             ||.||.....
Human   122 RMPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALA-------------ALPKDVPNSQ 173

  Fly   220 PSTLVEIEKSLLSLFNMKRPPKIDR--SKIIIPEPMKKLYAEIMGH------ELDSVNIPKPGLL 276
            |..:..::|.:|::.::|:.|.:.:  .|..:...::||:...:|.      |.|.....:...|
Human   174 PEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNEL 238

  Fly   277 TKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPAD-EKLKAAELQLTRDALSQQVVASRSS 340
            .:..:.:.:|....:.         |..|||::....:| ..::.||:.|         ......
Human   239 MEQTSEIITFAESGTA---------RKTLHFEISKEGSDLSVVERAEVWL---------FLKVPK 285

  Fly   341 ANRTRYQVLV----------------YDITRVGVRGQREPSYLLLDTKTVRLNSTD----TVSLD 385
            |||||.:|.:                .:...||::|:|  |.|||..|.|....:.    .||..
Human   286 ANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGER--SELLLSEKVVDARKSTWHVFPVSSS 348

  Fly   386 VQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTY------ 444
            :|..:|:..:|        ::||.                    |.|:.|.....|...
Human   349 IQRLLDQGKSS--------LDVRI--------------------ACEQCQESGASLVLLGKKKKK 385

  Fly   445 TDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRP----TRRKNHD----------------DTCRR 489
            .::|..|.:     .|||||......|.|..||    ..|::.|                :.|.:
Human   386 EEEGEGKKK-----GGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCK 445

  Fly   490 HSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLA--------------DHFNSTNHAVVQTLV 540
            ...:|.|.|:||:|||:||.||.|.||.|:||..:|              :|:....|:....|
Human   446 KQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANL- 509

  Fly   541 NNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587
                     |:|||||:|..::|||.:|...::.|:.|.|.|..|||
Human   510 ---------KSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	47/247 (19%)
		TGFB	487..588	CDD:214556	41/115 (36%)
INHBA	XP_016867663.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810