Protein Alignment dpp and INHBA

DIOPT Version :10

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: XP_054214132.1
• Gene: INHBA / 3624
• HGNCID: 6066
• Length: 548
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 138/632 - (21%)
• Similarity: 224/632 - (35%)
• Gaps: 196/632 - (31%)

  Fly    41 IPLASASGSGSG------RSGSRSVGASTSTALAKAFNPFSEPASFSDSDKSHRSKTNKKPSKSD 99
            :.||.|.|...|      ..|||...:....|.|...:|:..||..:..:...|.:..|.|.|.
Human    27 VALAGAQGKNRGCRLDRLGPGSRHPASWARAAAAFRRDPWKLPAGAAQENLLKRRRKKKTPKKK- 90

  Fly   100 ANRQFNEVHKPRTDQLENSKNKSKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESH 164
                                      :.|..|.|...:|...        ::...|:|..:|.:.
Human    91 --------------------------IKKSTHTKKPAREGGG--------KAGPFKKAITTTFAA 121

  Fly   165 QS----------SSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPD 219
            :.          :|...|....||...:...|:.:.|:.|.|             ||.||.....
Human   122 RMPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALA-------------ALPKDVPNSQ 173

  Fly   220 PSTLVEIEKSLLSLFNMKRPPKIDR--SKIIIPEPMKKLYAEIMGH------ELDSVNIPKPGLL 276
            |..:..::|.:|::.::|:.|.:.:  .|..:...::||:...:|.      |.|.....:...|
Human   174 PEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNEL 238

  Fly   277 TKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPAD-EKLKAAELQLTRDALSQQVVASRSS 340
            .:..:.:.:|....:.         |..|||::....:| ..::.||:.|         ......
Human   239 MEQTSEIITFAESGTA---------RKTLHFEISKEGSDLSVVERAEVWL---------FLKVPK 285

  Fly   341 ANRTRYQVLV----------------YDITRVGVRGQREPSYLLLDTKTVRLNSTD----TVSLD 385
            |||||.:|.:                .:...||::|:|  |.|||..|.|....:.    .||..
Human   286 ANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGER--SELLLSEKVVDARKSTWHVFPVSSS 348

  Fly   386 VQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTY------ 444
            :|..:|:..:|        ::||.                    |.|:.|.....|...
Human   349 IQRLLDQGKSS--------LDVRI--------------------ACEQCQESGASLVLLGKKKKK 385

  Fly   445 TDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRP----TRRKNHD----------------DTCRR 489
            .::|..|.:     .|||||......|.|..||    ..|::.|                :.|.:
Human   386 EEEGEGKKK-----GGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCK 445

  Fly   490 HSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLA--------------DHFNSTNHAVVQTLV 540
            ...:|.|.|:||:|||:||.||.|.||.|:||..:|              :|:....|:....|
Human   446 KQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANL- 509

  Fly   541 NNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587
                     |:|||||:|..::|||.:|...::.|:.|.|.|..|||
Human   510 ---------KSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	47/247 (19%)
		TGF_beta_DPP	480..588	CDD:381662	43/138 (31%)
INHBA	XP_054214132.1	TGFb_propeptide	178..376	CDD:480997	46/245 (19%)
		TGF_beta_INHBA	441..548	CDD:381674	41/117 (35%)