Protein Alignment dpp and BMP8A

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_861525.2
• Gene: BMP8A / 353500
• HGNCID: 21650
• Length: 402
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 122/401 - (30%)
• Similarity: 186/401 - (46%)
• Gaps: 80/401 - (19%)

  Fly   225 EIEKSLLSLFNM------KRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTV 283
            ::::.:|::..:      :.||...|.....|..|..||..:.|.: |....|....|.: |:.|
Human    43 DVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDD-DEDGAPAEQRLGR-ADLV 105

  Fly   284 RSFTH---KDSKIDDRFPHHHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTR 345
            .||.:   :|..:..:.||...||  ||:..|||.|.:.|||.::.:       |.|....|||.
Human   106 MSFVNMVERDRALGHQEPHWKEFR--FDLTQIPAGEAVTAAEFRIYK-------VPSIHLLNRTL 161

  Fly   346 YQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYG--LLVEVR 408
            : |.::.:  |..:..||.....||.:|:|......:.|||..|.|.||....::.|  |.||..
Human   162 H-VSMFQV--VQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETE 223

  Fly   409 TVRSLKP---------APHHHVRLRRSADEAHERWQHKQPLLFTY---TDDGRHKARSIRDVSGG 461
            ...|:.|         ||                 :.:||.:.|:   :.......|::|.:
Human   224 DGHSVDPGLAGLLGQRAP-----------------RSQQPFVVTFFRASPSPIRTPRAVRPL--- 268

  Fly   462 EGGGKGGRNKRQPRRPTR--------------RKNHD-DTCRRHSLYVDFSDVGWDDWIVAPLGY 511
                    .:|||::...              |.:|. ..||||.|||.|.|:||.||::||.||
Human   269 --------RRRQPKKSNELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGY 325

  Fly   512 DAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKN 576
            .||||.|:|.|||....|:||||::|:||:.|.|..||||||.||:|.:.::||.:..:.|:|:.
Human   326 SAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRK 390

  Fly   577 YQEMTVVGCGC 587
            ::.|.|..|||
Human   391 HRNMVVKACGC 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	60/238 (25%)
		TGFB	487..588	CDD:214556	54/101 (53%)
BMP8A	NP_861525.2	TGFb_propeptide	33..251	CDD:279078	60/238 (25%)
		TGF_beta	299..401	CDD:278448	52/101 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820