Protein Alignment dpp and daw

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001259967.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 124/626 - (19%)
• Similarity: 231/626 - (36%)
• Gaps: 180/626 - (28%)

  Fly    75 SEPASFSDSDKSHRSKTNKKPSKSDANRQFNEVH---KPRTDQLENSK----------------- 119
            |.|:|..|..:.| .|....|.....::|..:.|   :.|:.||::.:
  Fly    29 SHPSSRGDILRPH-PKHQPHPHVQHTSQQLQQQHHIRQQRSRQLKHLEPDPTSEEDDVPITKREY 92

  Fly   120 ---------NKSKQLV------NKPNHNKMAVKEQR------SHHKKSHHHRS----------HQ 153
                     :|.:.|:      |.|..:...:|..|      ...:|:|.|.|          ..
  Fly    93 YARLRRHVIHKRQHLLQQELSYNHPGSHSEQLKVPRLWQHLMEQEEKAHRHVSPPVELPIMYGDA 157

  Fly   154 PKQASASTESHQSSSIESIFVE-----------------------------EPTLVLDREVASIN 189
            |:::|.|::.|........||.                             ||.|.|.....:|:
  Fly   158 PEESSLSSDDHFDDLSPLDFVRNELMAEDQQNQEKDLDLDLDLDQQPETPIEPELPLGERNITIS 222

  Fly   190 VPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIE---KSLLSLFNMKRPPKIDRSKIIIPE 251
            |.::|..  ..:..|....|.:.:::|     |.:.||   :.:|....:|..||:  |.:.:|:
  Fly   223 VKSSAGG--CPKCESNRQVEHITEEQL-----THLRIEFVKQQILEKLRLKESPKV--SAVELPK 278

  Fly   252 PMKKLYAEIMGHELDSVNIPKPGLLTKS-------ANTVRSF-----------THKDSKIDDRFP 298
            |:           .|.:.:..|...||:       |.|.:.|           ..:|.|.:.
  Fly   279 PI-----------FDGMTLSHPDDSTKNKELDDYYARTSKKFILLNREEVECNRARDGKSNP--- 329

  Fly   299 HHHRFRLHFDVKSIPADEK---LKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRG 360
                 .:.|..|...||.:   :..|.|.|.:   ::|.....:|.|.|..|..:. ::.|.|..
  Fly   330 -----SMCFTFKIDDADAEGFDVSTAVLWLFK---NKQNRTDTASVNSTSAQQTIV-VSEVEVDQ 385

  Fly   361 QREPSYLLLDTKTVRLNSTDT----VSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHV 421
            |::..||.. .||:.:.|.:.    :.:|::..:..|::..:.::  |::: |......:....:
  Fly   386 QKDSKYLSA-AKTIAIQSVNVQDEWMKIDIEWPIKHWISGHELSH--LIQI-TCGGCDVSDMEEI 446

  Fly   422 RLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDT 486
               .|.|:.:      :|.:.....:.|.|:|..|.::...|                   ..:.
  Fly   447 ---ISVDKDY------RPFIVIDMQNRRRKSRQKRSINCSSG-------------------MTEC 483

  Fly   487 CRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGK---- 547
            ||.| ||:.|.|:||.:||:.|.||:||:|.|.|....:....:::|:.:..:::.....|
  Fly   484 CREH-LYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLEL 547

  Fly   548 VPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR 588
            ||  ||...|..|:.::.::..:|..:|....|.|..||||
  Fly   548 VP--CCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGCR 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	45/246 (18%)
		TGFB	487..588	CDD:214556	33/104 (32%)
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	47/256 (18%)
		TGF_beta	481..585	CDD:278448	32/106 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466515
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840