DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpp and bmp2a

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_571434.1	Gene:	bmp2a / 30631	ZFINID:	ZDB-GENE-980526-388	Length:	386	Species:	Danio rerio

Alignment Length:	413	Identity:	159/413 - (38%)
Similarity:	228/413 - (55%)	Gaps:	61/413 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 ANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKL 256
            |.:..::.:.|.|:.|            |..|...|..|||:|.::..|....| .::|:.|..|
Zfish    19 AGSSGLVPQVGRSSLS------------PDVLHAFELRLLSMFGLQHRPTPSTS-AVVPQYMLDL 70

  Fly   257 YAEIMGHELDSVNIPKP-GLLTKS-------ANTVRSFTHKDSKIDDRFPHHHRF--RLHFDVKS 311
            |:   .|.:::..:.:| ..|.|.       |||:||| |.|...:|......|.  |..|::.|
Zfish    71 YS---AHSVNAEQVSRPRAHLGKGSERSASRANTIRSF-HHDESTEDPSSSSVRTTQRFLFNLTS 131

  Fly   312 IPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRL 376
            ||.:|.:.:|::::.|    :|:|:|.::|:...:::.|::|.|.. ...:||...||||:.|:.
Zfish   132 IPDEELVTSADVRVFR----EQIVSSLNNASAGFHRINVHEIIRPS-GSLQEPITRLLDTRLVQH 191

  Fly   377 NSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPH------HHVRLRRSADEAHERWQ 435
            :.:...|.||.|||.:|......|:|:|||:         .|      .|||:.||.....:.|.
Zfish   192 SLSKWESFDVTPAVLKWTTDGHPNHGILVEI---------SHPDQDSRKHVRVSRSLHNNEDTWS 247

  Fly   436 HKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVG 500
            ..:|||.||:.||:             |.....|.|||.|...:||.|...||||||||||||||
Zfish   248 QMRPLLVTYSHDGK-------------GNVLHSREKRQARNNKQRKKHKANCRRHSLYVDFSDVG 299

  Fly   501 WDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLY 565
            |:||||||.||.|:||.|:||||||||.|||.:|:||||||::| ..:|:||||||.|..|::||
Zfish   300 WNDWIVAPPGYHAFYCQGECPFPLADHLNSTTNAMVQTLVNSVN-SNIPRACCVPTDLSPVSLLY 363

  Fly   566 LNDQSTVVLKNYQEMTVVGCGCR 588
            |::...|:|||||:|.|.|||||
Zfish   364 LDEYERVILKNYQDMVVEGCGCR 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	69/234 (29%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	69/100 (69%)
bmp2a	NP_571434.1	TGFb_propeptide	28..256	CDD:279078	74/258 (29%)
bmp2a	NP_571434.1	TGFB	286..386	CDD:214556	69/100 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3545
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H926
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2952
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002405
OrthoInspector	1	1.000	-	-		otm24629
orthoMCL	1	0.900	-	-		OOG6_105711
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3241
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.890