DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpp and lft1

DIOPT Version :9

Sequence 1:	NP_477311.1	Gene:	dpp / 33432	FlyBaseID:	FBgn0000490	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_571035.1	Gene:	lft1 / 30145	ZFINID:	ZDB-GENE-990630-10	Length:	358	Species:	Danio rerio

Alignment Length:	395	Identity:	87/395 - (22%)
Similarity:	151/395 - (38%)	Gaps:	101/395 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 EIEKSLLSLFNMKRPPKI---DRSKIIIPEPMKKLYAEI--MGHELDSVNIPK--------PGLL 276
            :::.:||....:...|:|   |...::||..:|..|..:  :.|.....::|.        ||
Zfish    25 DMKDALLKKLGLNEIPQIHKRDLENLVIPTHVKNKYISMLKLHHSRKRRSLPSLAGILRGIPG-- 87

  Fly   277 TKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKS-IPADEKLKAAELQLTRDALSQQVVASRSS 340
              :|:....|.:.|:.         |.|:.|::.| ||.:.::..|||:|.:.|..::.:..|..
Zfish    88 --NADISGEFVYSDTT---------RQRVVFEMTSRIPENSEVTMAELKLYKKAPHKRSIPERKG 141

  Fly   341 ---ANRTRYQVLVYDITRVGVRGQREPS--YLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRN 400
               .|..|  |.:|     .|..|::.|  ..|:|::.:.::.|...|.||..||..|..| :..
Zfish   142 HRPVNNAR--VSIY-----WVEPQKDGSNRTSLVDSRLIPIHETGWKSFDVTQAVQYWSRS-RME 198

  Fly   401 YGLLVEVRTVRSLKPAPHHHVRLRRSADEA---HERWQHK------QPLLFTYTDDGRHKARSIR 456
            ..:.:|| .:...:|..:       :|:.|   |...|..      :|.|..||
Zfish   199 MPMHLEV-WIEGERPGSY-------AAEMAKCVHFTTQDPDDNTLGKPELVLYT----------- 244

  Fly   457 DVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVGWDD-WIVAPLGYDAYYCHGKC 520
             ::..|.|..|.....:.|         :.|.|...:::|..:.|.. ||:.|.||.|:.|.|.|
Zfish   245 -LNLEEFGSSGDCENNKDR---------EMCCREQYFINFRALTWTQYWIIEPSGYQAFRCKGGC 299

  Fly   521 PFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYL---NDQSTVVLKNYQEMTV 582
            ..|                  ..|.|...:.|.| .:...:.|:||   .|.:.:.:..:..|.|
Zfish   300 RQP------------------KRNYGYGERKCAV-VESAPLPMMYLVKKGDYTEIEVAEFPNMIV 345

  Fly   583 VGCGC 587
            ..|||
Zfish   346 EKCGC 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	54/246 (22%)
dpp	NP_477311.1	TGFB	487..588	CDD:214556	27/105 (26%)
lft1	NP_571035.1	TGFb_propeptide	24..>192	CDD:366248	43/186 (23%)
lft1	NP_571035.1	TGF_beta_LEFTY1_2	265..350	CDD:381636	25/103 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810