Protein Alignment dpp and BMP10

DIOPT Version :9

• Sequence 1: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_055297.1
• Gene: BMP10 / 27302
• HGNCID: 20869
• Length: 424
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 117/402 - (29%)
• Similarity: 187/402 - (46%)
• Gaps: 59/402 - (14%)

  Fly   219 DPSTLVE-IEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANT 282
            |.:||:: ::...|...|:...|..|.:|:..||.|.:||.:.   ..|..::|       |||.
Human    50 DFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKF---ATDRTSMP-------SANI 104

  Fly   283 VRSFTHKDSKIDD-RFPHHHRFRLHFDVKSIPADEKLKAAELQL----TRDALSQQVVASRSSAN 342
            :|||.::|..... .|....::.|.|:| |||..|::..|||:|    .||.:....|..:
Human   105 IRSFKNEDLFSQPVSFNGLRKYPLLFNV-SIPHHEEVIMAELRLYTLVQRDRMIYDGVDRK---- 164

  Fly   343 RTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEV 407
                 :.::::.......:.|.:.|:|.:..:...:::..:.||..|:.||..|....:.|.|.:
Human   165 -----ITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHI 224

  Fly   408 RTVR-SLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDD---GRHKARSIRDVSGGE------ 462
            .:.. ..:.|....:.:..||...|      .|||..::||   .:.:...:.::...|
Human   225 ESKHDEAEDASSGRLEIDTSAQNKH------NPLLIVFSDDQSSDKERKEELNEMISHEQLPELD 283

  Fly   463 -------GGGKGGRNKRQPR--------RPTRRKNHDDTCRRHSLYVDFSDVGWDDWIVAPLGYD 512
                   ..|.|.....|.|        ...||....:.|:|..||:||.::|||.||:||.||:
Human   284 NLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYE 348

  Fly   513 AYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLK-N 576
            ||.|.|.|.:|||:|...|.||::|.||:..|..|..|||||||:|:.:::||| |:..|..| .
Human   349 AYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYL-DKGVVTYKFK 412

  Fly   577 YQEMTVVGCGCR 588
            |:.|.|..||||
Human   413 YEGMAVSECGCR 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:279078	52/225 (23%)
		TGFB	487..588	CDD:214556	51/101 (50%)
BMP10	NP_055297.1	TGFb_propeptide	55..256	CDD:279078	52/226 (23%)
		TGF_beta	321..423	CDD:278448	50/102 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810